口腔舌鳞状细胞癌中宿主免疫微环境的组织学评价及其预后意义：淋巴细胞宿主反应（LHR）和肿瘤浸润淋巴细胞（TILs）的对比研究。
Histologic evaluation of host immune microenvironment and its prognostic significance in oral tongue squamous cell carcinoma: a comparative study on lymphocytic host response (LHR) and tumor infiltrating lymphocytes (TILs).
机构信息
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Pathol Res Pract. 2021 Dec;228:153473. doi: 10.1016/j.prp.2021.153473. Epub 2021 May 10.
BACKGROUND
Host immune microenvironment is a key component of anti-tumoral immune response, influencing tumor progression, regression, and treatment responses. There is a need for simple and reliable histologic measurements of host immune response in routine histopathologic diagnosis.
METHODS
The prognostic value of lymphocytic host response (LHR), a qualitative histologic grading scheme, was compared to stromal/intratumoral TIL (sTIL/iTIL) percentage, a quantitative measurement in a retrospective study of 329 patients with oral tongue squamous cell carcinoma (OTSCC) of 4 cm or less in size.
RESULTS
High sTIL predicted improved distant recurrence free survival on univariate survival analysis and was an independent prognostic factor for better overall survival on multivariate analysis. LHR and iTIL were not associated with the risk of nodal metastasis or outcome.
CONCLUSIONS
sTIL appears to be a superior quantitative histologic measurement for the host immune microenvironment compared with the qualitative LHR grading scheme. sTIL is an independent prognostic factor for overall survival in OTSCC.
背景
宿主免疫微环境是抗肿瘤免疫反应的关键组成部分，影响肿瘤的进展、消退和治疗反应。在常规组织病理学诊断中，需要一种简单可靠的宿主免疫反应的组织学测量方法。
方法
在一项回顾性研究中，比较了淋巴细胞宿主反应（LHR）作为定性组织学分级方案与间质/肿瘤内 TIL（sTIL/iTIL）百分比的预后价值，该研究纳入了 329 例大小为 4cm 或以下的口腔舌鳞状细胞癌（OTSCC）患者。
结果
sTIL 高预示着无远处复发生存时间的改善，在单因素生存分析中是独立的预后因素，在多因素分析中是总生存时间的更好的预后因素。LHR 和 iTIL 与淋巴结转移风险或结局无关。
结论
与定性 LHR 分级方案相比，sTIL 似乎是宿主免疫微环境的一种更优的定量组织学测量方法。sTIL 是 OTSCC 总生存的独立预后因素。
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