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环状 RNA 0102049 通过调控 miR-520g-3p/PLK2 轴抑制骨肉瘤的进展。

Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.

机构信息

Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

Department of Orthopedics, Shaoguan First People's Hospital Affiliated to Southern Medical University, Shaoguan, China.

出版信息

Bioengineered. 2021 Dec;12(1):2022-2032. doi: 10.1080/21655979.2021.1923259.

DOI:10.1080/21655979.2021.1923259
PMID:34060415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8806202/
Abstract

Circular RNAs (circRNAs) are a type of non-coding RNAs generated from back splicing to enhance or inhibit the progression of multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found to be highly expressed in OS cell lines, the role and specific mechanism of circ_0102049 in OS remains unclear. Here, we found that silence of circ_0102049 could significantly exacerbate the tumorigenesis of OS through sponging microRNA-520g-3p. Polo-like kinase 2 (PLK2) was predicted to be a target of miR-520g-3p, and luciferase reporter assay revealed that overexpression of miR-520g-3p dramatically suppressed the expression of PLK2, whereas miR-520g-3p inhibitor promoted the PLK2 expression. Moreover, the silence of circ_0102049 could markedly promote the proliferation, invasion, migration and cell-cycle promotion while inhibiting the apoptosis of OS cell line MG63 cells through regulating miR-520g-3p/PLK2 axis. Taken together, the present study indicated that circ_0102049 suppressed the progression of osteosarcoma via modulating miR-520g-3p/PLK2/TAp73 axis, providing a potential therapeutic target for OS.

摘要

环状 RNA（circRNAs）是一种通过反向剪接产生的非编码 RNA，可增强或抑制多种人类癌症的进展，包括骨肉瘤（OS）。尽管已经发现 circ_0102049 在 OS 细胞系中高度表达，但 circ_0102049 在 OS 中的作用和具体机制仍不清楚。在这里，我们发现沉默 circ_0102049 通过海绵 microRNA-520g-3p 可以显著加剧 OS 的肿瘤发生。Polo 样激酶 2（PLK2）被预测为 miR-520g-3p 的靶标，荧光素酶报告基因检测显示过表达 miR-520g-3p 可显著抑制 PLK2 的表达，而 miR-520g-3p 抑制剂则促进 PLK2 的表达。此外，沉默 circ_0102049 通过调节 miR-520g-3p/PLK2/TAp73 轴可以显著促进 OS 细胞系 MG63 细胞的增殖、侵袭、迁移和细胞周期促进，同时抑制细胞凋亡。综上所述，本研究表明 circ_0102049 通过调节 miR-520g-3p/PLK2/TAp73 轴抑制骨肉瘤的进展，为骨肉瘤提供了一个潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/edc9561d3c3d/KBIE_A_1923259_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/c4dfb304f197/KBIE_A_1923259_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/e784f4dd96bd/KBIE_A_1923259_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/6ad58b3439a8/KBIE_A_1923259_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/048c17857439/KBIE_A_1923259_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/aac6bf88b6cb/KBIE_A_1923259_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/edc9561d3c3d/KBIE_A_1923259_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/c4dfb304f197/KBIE_A_1923259_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/e784f4dd96bd/KBIE_A_1923259_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/6ad58b3439a8/KBIE_A_1923259_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/048c17857439/KBIE_A_1923259_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/aac6bf88b6cb/KBIE_A_1923259_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c5/8806202/edc9561d3c3d/KBIE_A_1923259_F0005_OC.jpg

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