Cheung W T, Lee C M, Ng T B
Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong.
Pharmacology. 1988;36(5):331-9. doi: 10.1159/000138403.
The effect of chronic caffeine treatment on lipolysis in rat epididymal adipose tissue was studied. There was a decrease in body weight, epididymal fat pad weight and mean adipocyte diameter in caffeine-treated rats when compared with control rats. No difference in adipocyte triglyceride content or mean adipocyte weight between control and caffeine-treated rats was observed. Lipolysis in adipocytes induced by adenosine deaminase (1 U/ml) decreased by 35% in caffeine-treated rats. This was accompanied by a 2.5-fold increase in the anti-lipolytic potency of 2-chloroadenosine and an increase of adipocyte adenosine A1 receptor number.
研究了慢性咖啡因处理对大鼠附睾脂肪组织脂解作用的影响。与对照大鼠相比，咖啡因处理的大鼠体重、附睾脂肪垫重量和平均脂肪细胞直径均有所下降。对照大鼠和咖啡因处理的大鼠之间，脂肪细胞甘油三酯含量或平均脂肪细胞重量没有差异。咖啡因处理的大鼠中，腺苷脱氨酶（1 U/ml）诱导的脂肪细胞脂解作用降低了35%。这伴随着2-氯腺苷抗脂解效力增加2.5倍以及脂肪细胞腺苷A1受体数量增加。
