College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.
Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20210443.
To facilitate temperature adjustments, the testicles are located outside the body cavity. In most mammals, the temperature of the testes is lower than the body temperature to ensure the normal progression of spermatogenesis. Rising temperatures affect spermatogenesis and eventually lead to a decline in male fertility or even infertility. However, the testes are composed of different cell types, including spermatogonial stem cells (SSCs), spermatocytes, spermatozoa, Leydig cells, and Sertoli cells, which have different cellular responses to heat stress. Recent studies have shown that using different drugs can relieve heat stress-induced reproductive damage by regulating different signaling pathways. Here, we review the mechanisms by which heat stress damages different cells in testes and possible treatments.
为了便于调节温度，睾丸位于体腔外。在大多数哺乳动物中，睾丸的温度低于体温，以确保精子发生的正常进行。温度升高会影响精子发生，最终导致男性生育力下降，甚至不育。然而，睾丸由不同的细胞类型组成，包括精原干细胞（SSCs）、精母细胞、精子、间质细胞和支持细胞，它们对热应激的细胞反应不同。最近的研究表明，通过调节不同的信号通路，使用不同的药物可以缓解热应激引起的生殖损伤。在这里，我们综述了热应激损伤睾丸不同细胞的机制以及可能的治疗方法。
