Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Trav. La Crucca 3, I-07100 Sassari, Italy.
Dipartimento di Chimica e Farmacia, Universita di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
Curr Med Chem. 2021;28(35):7339-7384. doi: 10.2174/0929867328666210531144021.
Biospeciation of some of the most studied vanadium (symbol V) complexes with biological or medicinal activity is discussed in this review in order to emphasize the importance of the distribution of V species in biological media. The exact knowledge of the chemical species present in blood or cells may provide essential information regarding the biological effect of V potential drugs. In blood serum, vanadium species can interact with low (citrate, lactate, oxalate, amino acids, etc., indicated with bL) and high molecular mass (proteins like transferrin, albumin, immunoglobulins, etc.) components, while the interaction with red blood cells can interfere with the transport of these drugs towards the target cells. The interaction of bLs and proteins is discussed through the analysis of instrumental and computational data. The fate of the active V species, when these are in the real serum samples and when they reach and cross cell membranes, is also discussed. The differences in the V complexes selected in this review (donor atoms, stability, coordination geometry, electric charge, hydrolipophilicity balance, substituents and redox properties) cover all the possible modes of interaction with bLs and proteins, allowing for the biodistribution of the studied compounds to be predicted. This approach could be applied to newly synthesized potential V drugs.
本文讨论了一些具有生物或医学活性的最受研究的钒（符号 V）配合物的生物种形成，以强调在生物介质中 V 物种分布的重要性。准确了解血液或细胞中存在的化学物质可能为 V 类潜在药物的生物学效应提供重要信息。在血清中，钒物种可以与低（柠檬酸、乳酸盐、草酸盐、氨基酸等，用 bL 表示）和高分子质量（如转铁蛋白、白蛋白、免疫球蛋白等）成分相互作用，而与红细胞的相互作用可能会干扰这些药物向靶细胞的运输。通过分析仪器和计算数据讨论了 bLs 和蛋白质的相互作用。还讨论了当这些活性 V 物种存在于实际血清样本中以及当它们到达并穿过细胞膜时的命运。本综述中选择的 V 配合物（供体原子、稳定性、配位几何、电荷、亲脂-亲水平衡、取代基和氧化还原性质）的差异涵盖了与 bLs 和蛋白质相互作用的所有可能模式，从而可以预测研究化合物的生物分布。这种方法可以应用于新合成的潜在 V 类药物。
