Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia.
College of Medical Laboratory Science, Omdurman Islamic University, Omdurman 825109, Sudan.
Int J Environ Res Public Health. 2021 May 1;18(9):4852. doi: 10.3390/ijerph18094852.
The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.
男性乳腺癌的全球发病率正在稳步上升。尽管如此，与女性乳腺癌患者相比，针对男性乳腺癌患者生物标志物的研究却非常少。本研究通过开展病例对照研究，旨在确定男性乳腺癌患者的褪黑素、胃饥饿素、多巴胺、血清素、肾上腺素和 GABA 血清水平。所有入组患者均肥胖、年龄较大且最近被诊断患有该疾病。在研究时，他们均未接受任何癌症治疗。与年龄匹配的对照组相比，乳腺癌患者的褪黑素和肾上腺素血清水平显著升高，而与对照组相比，患者的胃饥饿素、多巴胺、GABA 和血清素血清水平较低。男性乳腺癌患者的大多数研究生物标志物的血清水平与女性乳腺癌患者的观察结果相似，除了血清褪黑素水平。
