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小儿脑肿瘤中Ras、TrkB和ShcA蛋白的表达模式

Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.

作者信息

Prill Monika, Karkucinska-Wieckowska Agnieszka, Lebiedzinska-Arciszewska Magdalena, Morciano Giampaolo, Charzynska Agata, Dabrowski Michal, Pronicki Maciej, Pinton Paolo, Grajkowska Wieslawa, Wieckowski Mariusz R

机构信息

Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.

Department of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.

出版信息

J Clin Med. 2021 May 20;10(10):2219. doi: 10.3390/jcm10102219.

DOI:10.3390/jcm10102219
PMID:34065573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8160917/
Abstract

Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins.

摘要

众多论文报道了Ras和/或ShcA蛋白在不同类型癌症中的表达模式改变。它们的水平可能与致癌过程相关。我们分析了小儿脑肿瘤样本，这些样本反映了不同的组别，如脉络丛肿瘤、弥漫性星形细胞和少突胶质细胞瘤、胚胎性肿瘤、室管膜瘤以及其他星形细胞瘤，还有肿瘤恶性程度分级，以表征Ras、TrkB和ShcA的三种异构体（即p66Shc、p52Shc和p46Shc蛋白）的表达谱。我们研究的主要目的是评估小儿脑肿瘤类型、肿瘤恶性程度分级与所研究蛋白质表达模式之间的潜在相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/24dd2412088d/jcm-10-02219-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/ae5fc184bba2/jcm-10-02219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/9b6169437643/jcm-10-02219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/09eaf77291f2/jcm-10-02219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/2304f174f021/jcm-10-02219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/8896afe63d3d/jcm-10-02219-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/b414428e3fe1/jcm-10-02219-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/ee5a0b55d0b2/jcm-10-02219-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/1a1f050268b8/jcm-10-02219-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/5aa059fe0817/jcm-10-02219-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/24dd2412088d/jcm-10-02219-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/ae5fc184bba2/jcm-10-02219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/9b6169437643/jcm-10-02219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/09eaf77291f2/jcm-10-02219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/2304f174f021/jcm-10-02219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/8896afe63d3d/jcm-10-02219-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/b414428e3fe1/jcm-10-02219-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/ee5a0b55d0b2/jcm-10-02219-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/1a1f050268b8/jcm-10-02219-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/5aa059fe0817/jcm-10-02219-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bb7/8160917/24dd2412088d/jcm-10-02219-g010.jpg

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本文引用的文献

1
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.毛细胞型星形细胞瘤：一般特征、临床特征和分子特征的综述。
J Child Neurol. 2020 Oct;35(12):852-858. doi: 10.1177/0883073820937225. Epub 2020 Jul 20.
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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.癌症生物学中个体RAS突变的比较分析
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Medulloblastoma in the age of molecular subgroups: a review.分子亚组时代的髓母细胞瘤：综述
J Neurosurg Pediatr. 2019 Oct 1;24(4):353-363. doi: 10.3171/2019.5.PEDS18381.
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P66shc and its role in ischemic cardiovascular diseases.P66shc 及其在缺血性心血管疾病中的作用。
Basic Res Cardiol. 2019 Jun 4;114(4):29. doi: 10.1007/s00395-019-0738-x.
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Childhood brain tumors: current management, biological insights, and future directions.儿童脑肿瘤：当前的治疗、生物学见解及未来方向
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The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy.PKCβ-p66shc-NADPH 氧化酶通路在糖尿病肾病中起着至关重要的作用。
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Case-based review: pediatric medulloblastoma.基于病例的综述：小儿髓母细胞瘤
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Oncotarget. 2017 Jul 25;8(59):99394-99401. doi: 10.18632/oncotarget.19561. eCollection 2017 Nov 21.
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RAS Proteins and Their Regulators in Human Disease.人类疾病中的RAS蛋白及其调节因子
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COSMIC: somatic cancer genetics at high-resolution.COSMIC：高分辨率体细胞癌遗传学
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