小儿脑肿瘤中Ras、TrkB和ShcA蛋白的表达模式

Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.

作者信息

Prill Monika, Karkucinska-Wieckowska Agnieszka, Lebiedzinska-Arciszewska Magdalena, Morciano Giampaolo, Charzynska Agata, Dabrowski Michal, Pronicki Maciej, Pinton Paolo, Grajkowska Wieslawa, Wieckowski Mariusz R

机构信息

Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.

Department of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.

出版信息

J Clin Med. 2021 May 20;10(10):2219. doi: 10.3390/jcm10102219.

DOI:10.3390/jcm10102219

PMID:34065573

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8160917/

Abstract

Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins.

摘要

众多论文报道了Ras和/或ShcA蛋白在不同类型癌症中的表达模式改变。它们的水平可能与致癌过程相关。我们分析了小儿脑肿瘤样本，这些样本反映了不同的组别，如脉络丛肿瘤、弥漫性星形细胞和少突胶质细胞瘤、胚胎性肿瘤、室管膜瘤以及其他星形细胞瘤，还有肿瘤恶性程度分级，以表征Ras、TrkB和ShcA的三种异构体（即p66Shc、p52Shc和p46Shc蛋白）的表达谱。我们研究的主要目的是评估小儿脑肿瘤类型、肿瘤恶性程度分级与所研究蛋白质表达模式之间的潜在相关性。