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以水作为血液模型测定膜式氧合器的二氧化碳清除性能

Water as a Blood Model for Determination of CO Removal Performance of Membrane Oxygenators.

作者信息

Lukitsch Benjamin, Koller Raffael, Ecker Paul, Elenkov Martin, Janeczek Christoph, Pekovits Markus, Haddadi Bahram, Jordan Christian, Gfoehler Margit, Harasek Michael

机构信息

Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, Austria.

Institute of Engineering Design and Product Development, TU Wien, 1060 Vienna, Austria.

出版信息

Membranes (Basel). 2021 May 12;11(5):356. doi: 10.3390/membranes11050356.

DOI:10.3390/membranes11050356
PMID:34066152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8151077/
Abstract

CO removal via membrane oxygenators has become an important and reliable clinical technique. Nevertheless, oxygenators must be further optimized to increase CO removal performance and to reduce severe side effects. Here, in vitro tests with water can significantly reduce costs and effort during development. However, they must be able to reasonably represent the CO removal performance observed with blood. In this study, the deviation between the CO removal rate determined in vivo with porcine blood from that determined in vitro with water is quantified. The magnitude of this deviation (approx. 10%) is consistent with results reported in the literature. To better understand the remaining difference in CO removal rate and in order to assess the application limits of in vitro water tests, CFD simulations were conducted. They allow to quantify and investigate the influences of the differing fluid properties of blood and water on the CO removal rate. The CFD results indicate that the main CO transport resistance, the diffusional boundary layer, behaves generally differently in blood and water. Hence, studies of the CO boundary layer should be preferably conducted with blood. In contrast, water tests can be considered suitable for reliable determination of the total CO removal performance of oxygenators.

摘要

通过膜式氧合器去除一氧化碳已成为一项重要且可靠的临床技术。然而，仍需进一步优化氧合器，以提高一氧化碳去除性能并减少严重的副作用。在此，用水进行体外测试可显著降低开发过程中的成本和工作量。然而，它们必须能够合理地反映用血液观察到的一氧化碳去除性能。在本研究中，对用猪血液在体内测定的一氧化碳去除率与用水在体外测定的一氧化碳去除率之间的偏差进行了量化。该偏差的幅度（约10%）与文献报道的结果一致。为了更好地理解一氧化碳去除率的剩余差异，并评估体外水测试的应用局限性，进行了计算流体动力学（CFD）模拟。这些模拟能够量化并研究血液和水不同的流体特性对一氧化碳去除率的影响。CFD结果表明，主要的一氧化碳传输阻力——扩散边界层，在血液和水中的表现通常不同。因此，一氧化碳边界层的研究最好使用血液进行。相比之下，水测试可被认为适合可靠地测定氧合器的总一氧化碳去除性能。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/bc419b5c5b97/membranes-11-00356-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/29a02daca19f/membranes-11-00356-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/4831ccfff327/membranes-11-00356-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/9c47d3e68c2e/membranes-11-00356-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/f9a081d716f2/membranes-11-00356-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/c189a9981492/membranes-11-00356-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/c5704648143b/membranes-11-00356-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3274/8151077/a51a1959b958/membranes-11-00356-g020.jpg

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