Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Cells. 2021 May 6;10(5):1114. doi: 10.3390/cells10051114.
The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8 T cells because of their cytotoxic effector function; however, CD4 T cells are crucial in the proper development of these long-lasting effector CD8 T cells. In this review, we summarize what is known about CD4 T cells in chronic HBV infection and discuss the importance and opportunities of including CD4 T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
在慢性乙型肝炎（HBV）患者中观察到的 T 细胞功能受损被认为是导致感染慢性化的原因之一。由于 CD8 T 细胞具有细胞毒性效应功能，因此针对这种损伤的研究主要集中在 CD8 T 细胞上；然而，CD4 T 细胞在这些持久的效应 CD8 T 细胞的正常发育中至关重要。在这篇综述中，我们总结了慢性 HBV 感染中 CD4 T 细胞的已知知识，并讨论了在以 T 细胞为导向的免疫治疗策略中纳入 CD4 T 细胞以治愈慢性 HBV 的重要性和机会。
