Bouba Ioanna, Hatzi Elissavet, Ladias Paris, Sakaloglou Prodromos, Kostoulas Charilaos, Georgiou Ioannis
Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
IVF and Genetics Unit, Dept of Obstetrics and Gynecology, University Hospital of Ioannina, 45500 Ioannina, Greece.
J Dev Biol. 2021 May 7;9(2):18. doi: 10.3390/jdb9020018.
Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded from transfer. In the light of published contemporary studies, with or without clinical outcomes, there is growing evidence that mosaic embryos have the capacity for further in utero development and live birth. Our in-depth discussion will enable readers to better comprehend current developments. This expansion into the spectrum of ART practices requires further evidence and further theoretical documentation, basic research, and ethical support. Therefore, if strict criteria for selecting competent mosaic preimplantation embryos for further transfer, implantation, fetal growth, and healthy birth are applied, fewer embryos will be excluded, and more live births will be achieved. Our review aims to discuss the recent literature on the transfer of mosaic preimplantation embryos. It also highlights controversies as far as the clinical utilization of preimplantation embryos concerns. Finally, it provides the appropriate background to elucidate and highlight cellular and genetic aspects of this novel direction.
辅助生殖技术的应用和适应症正在不断扩大，但每一种新方法都受到严格审查和全面考量。最近，一些辅助生殖专家小组公布的数据支持了囊胚期嵌合植入前胚胎的临床应用，这类胚胎此前被排除在移植范围之外。根据已发表的当代研究，无论有无临床结果，越来越多的证据表明，嵌合胚胎具有在子宫内进一步发育并实现活产的能力。我们的深入讨论将使读者更好地理解当前的进展。这种对辅助生殖技术实践范围的扩展需要更多的证据、进一步的理论论证、基础研究和伦理支持。因此，如果应用严格的标准来选择有能力的嵌合植入前胚胎进行进一步移植、着床、胎儿生长和健康分娩，将会有更少的胚胎被排除，从而实现更多的活产。我们的综述旨在讨论近期关于嵌合植入前胚胎移植的文献。它还突出了在植入前胚胎临床应用方面存在的争议。最后，它提供了适当的背景知识，以阐明和突出这一新颖方向的细胞和遗传方面。
