Avishai Gal, Rabinovich Idan, Gilat Hanna, Chaushu Gavriel, Chaushu Liat
Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Petach-Tikva 49414, Israel.
Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.
Biology (Basel). 2021 May 7;10(5):414. doi: 10.3390/biology10050414.
Sialolithiasis is a chronic disease in which a sialolith (salivary stone) causes recurrent inflammation of the affected salivary gland. Anemia of inflammation is a well-described pathology in which a chronic inflammatory disease leads to a reduction in the red blood cell count, hemoglobin and hematocrit values. In this retrospective cohort study, we aim to find whether removal of the sialolith and alleviation of the inflammation affect the complete blood count results. We examined data regarding forty-nine patients who underwent surgery for the removal of a submandibular gland sialolith using the duct-stretching technique. Complete blood counts two years before and after the surgical procedure were collected. The average pre-procedure and post-procedure values were calculated for each patient to establish the average blood profile. The pre- and post-procedure values were compared to evaluate the effect of the surgical treatment on the blood profile. We found that the average blood count values for patients with sialolithiasis were towards the lower end of the normal range. Post-surgery, a significant increase in hematocrit, hemoglobin and red blood cell count was observed, which was more pronounced in the older age group and in patients with co-morbidities. We conclude that sialolith removal surgery is associated with significant improvement in the complete blood count values, especially in the elderly and in patients and with co-morbidities. The speculated pathogenesis is relative anemia of inflammation.
涎石病是一种慢性病，其中涎石（唾液腺结石）会导致受累唾液腺反复发炎。炎症性贫血是一种已被充分描述的病理状况，即慢性炎症性疾病导致红细胞计数、血红蛋白和血细胞比容值降低。在这项回顾性队列研究中，我们旨在探究涎石清除和炎症缓解是否会影响全血细胞计数结果。我们检查了49例采用导管扩张技术进行手术切除下颌下腺涎石患者的数据。收集了手术前后两年的全血细胞计数。计算每位患者术前和术后的平均值以确定平均血液状况。比较术前和术后的值以评估手术治疗对血液状况的影响。我们发现，涎石病患者的平均血细胞计数处于正常范围的下限。术后，观察到血细胞比容、血红蛋白和红细胞计数显著增加，在老年组和患有合并症的患者中更为明显。我们得出结论，涎石清除手术与全血细胞计数显著改善相关，尤其是在老年人以及患有合并症的患者中。推测的发病机制是相对性炎症性贫血。
