铅中毒大鼠氨基乙酰丙酸脱水酶的加热再激活作用。
Heating reactivation of rats aminolevulinic acid dehydratase in lead poisoning.
作者信息
Trevisan A, Raimondi M, Bungaro A, Chiesura P
机构信息
Istituto di Medicina del Lavoro, Università di Padova, Italy.
出版信息
Sci Total Environ. 1988 Jun 1;71(3):547-50. doi: 10.1016/0048-9697(88)90233-1.
Heat reactivation (60 degrees C for 5 minutes) of the red blood cells aminolevulinic acid dehydratase activity was studied in lead treated rats (0.25 to 5.0 mg/kg b.w., i.p., for 4 weeks). Complete enzyme reactivation occurs with lead blood concentration up to about 70 mcg/dl. At higher blood lead concentrations, only a part of the enzyme can be restored by heating. The different mechanisms of aminolevulinic acid dehydratase activity inhibition by lead are discussed.
在经铅处理的大鼠（腹腔注射，剂量为0.25至5.0毫克/千克体重，持续4周）中，研究了红细胞氨基乙酰丙酸脱水酶活性的热激活作用（60摄氏度，5分钟）。当血铅浓度高达约70微克/分升时，酶可完全重新激活。在更高的血铅浓度下，只有一部分酶可通过加热恢复。文中讨论了铅抑制氨基乙酰丙酸脱水酶活性的不同机制。
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