金属离子对δ-氨基乙酰丙酸脱水酶活性的影响。
The effect of metal ions on the activity of delta-aminolevulinic acid dehydratase.
作者信息
Thompson J, Jones D D, Beasley W H
出版信息
Br J Ind Med. 1977 Feb;34(1):32-6. doi: 10.1136/oem.34.1.32.
Abstract
The effects of lead, iron, copper, and zinc ions on delta-aminolevulinic acid dehydratase from red blood cell haemolysates in humans, both in the absence and presence of plasma proteins, have been investigated. delta-aminolevulinic acid dehydratase (ALAD) was not found to be a specific indicator of blood lead concentrations since it was also inhibited by copper and activated by zinc. Plasma protein protected the enzyme from both inhibition and activation. ALAD activity was found to be an indicator of the total metal ion concentration in the blood and was therefore considered to be of doubtful value in screening large populations for increased lead absorption.
摘要
研究了铅、铁、铜和锌离子对人红细胞溶血产物中δ-氨基乙酰丙酸脱水酶的影响，包括有无血浆蛋白存在的情况。未发现δ-氨基乙酰丙酸脱水酶（ALAD）是血铅浓度的特异性指标，因为它也会受到铜的抑制和锌的激活。血浆蛋白可保护该酶免受抑制和激活。发现ALAD活性是血液中总金属离子浓度的一个指标，因此在筛查大量人群铅吸收增加方面被认为价值存疑。
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