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严重急性呼吸综合征冠状病毒2型疫苗短缺情况下开放医院容量的最大化——一种开放获取的随机模拟工具

Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines-An Open Access, Stochastic Simulation Tool.

作者信息

Bosbach Wolfram A, Heinrich Martin, Kolisch Rainer, Heiss Christian

机构信息

Experimental Trauma Surgery, Justus Liebig University of Giessen, 35392 Giessen, Germany.

Department of Trauma, Hand, and Reconstructive Surgery, University Hospital of Giessen, 35385 Giessen, Germany.

出版信息

Vaccines (Basel). 2021 May 22;9(6):546. doi: 10.3390/vaccines9060546.

Abstract

The Covid-19 pandemic has led to the novel situation that hospitals must prioritize staff for a vaccine rollout while there is acute shortage of the vaccine. In spite of the availability of guidelines from state agencies, there is partial confusion about what an optimal rollout plan is. This study investigates effects in a hospital model under different rollout schemes. A simulation model is implemented in VBA, and is studied for parameter variation in a predefined hospital setting. The implemented code is available as open access supplement. A rollout scheme assigning vaccine doses to staff primarily by staff's pathogen exposure maximizes the predicted open hospital capacity when compared to a rollout based on a purely hierarchical prioritization. The effect increases under resource scarcity and greater disease activity. Nursing staff benefits most from an exposure focused rollout. . The model employs SARS-CoV-2 parameters; nonetheless, effects observable in the model are transferable to other infectious diseases. Necessary future prioritization plans need to consider pathogen characteristics and social factors.

摘要

新冠疫情导致了一种新情况,即在疫苗严重短缺的情况下,医院必须优先为工作人员开展疫苗接种。尽管有国家机构发布的指导方针,但对于什么是最佳接种计划仍存在部分困惑。本研究调查了不同接种方案在医院模型中的效果。在VBA中实现了一个模拟模型,并在预定义的医院环境中研究其参数变化。所实现的代码作为开放获取补充资料提供。与基于纯粹等级优先排序的接种方案相比,主要根据工作人员的病原体暴露情况为其分配疫苗剂量的接种方案能使预测的医院开放容量最大化。在资源稀缺和疾病活动增加的情况下,这种效果会增强。护理人员从以暴露为重点的接种方案中受益最大。该模型采用了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的参数;尽管如此,模型中可观察到的效果可转移到其他传染病。未来必要的优先排序计划需要考虑病原体特征和社会因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3da/8224649/200c5f3b09c9/vaccines-09-00546-g001.jpg

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