EMP3 在调节 IDH 野生型神经胶质瘤相关膜受体中的多功能作用。
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma.
机构信息
Clinical Cooperation Unit (CCU) Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Department of Neuropathology, Heidelberg University Medical Center, 69120 Heidelberg, Germany.
出版信息
Int J Mol Sci. 2021 May 17;22(10):5261. doi: 10.3390/ijms22105261.
Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM.
上皮膜蛋白 3（EMP3）是一种在异柠檬酸脱氢酶野生型（IDH-wt）脑胶质瘤（GBM）中过表达的四跨膜蛋白。几项研究报告称，EMP3 水平高是 GBM 患者预后不良的一个因素。基于神经胶质瘤和非神经胶质瘤模型的实验结果表明，EMP3 在调节几种已知的膜蛋白方面发挥作用，这些蛋白可驱动 IDH-wt GBM。在这篇综述中，我们总结了目前已知的关于 EMP3 生物学的知识。我们讨论了 EMP3 对各种致癌受体的调节作用，并讨论了这些机制如何与 IDH-wt GBM 相关。最后，我们列举了 EMP3 在 IDH-wt GBM 中的功能方面存在的一些问题。
Zotero 插件