Clinical Cooperation Unit (CCU) Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Department of Neuropathology, Heidelberg University Medical Center, 69120 Heidelberg, Germany.
Int J Mol Sci. 2021 May 17;22(10):5261. doi: 10.3390/ijms22105261.
Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM.
上皮膜蛋白 3（EMP3）是一种在异柠檬酸脱氢酶野生型（IDH-wt）脑胶质瘤（GBM）中过表达的四跨膜蛋白。几项研究报告称，EMP3 水平高是 GBM 患者预后不良的一个因素。基于神经胶质瘤和非神经胶质瘤模型的实验结果表明，EMP3 在调节几种已知的膜蛋白方面发挥作用，这些蛋白可驱动 IDH-wt GBM。在这篇综述中，我们总结了目前已知的关于 EMP3 生物学的知识。我们讨论了 EMP3 对各种致癌受体的调节作用，并讨论了这些机制如何与 IDH-wt GBM 相关。最后，我们列举了 EMP3 在 IDH-wt GBM 中的功能方面存在的一些问题。
