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交叉寄养对高酒精偏爱（HA）和低酒精偏爱（LA）小鼠酒精摄入量及类抑郁行为的影响：内源性阿片系统的作用

The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System.

作者信息

Nawrocka Agata, Poznański Piotr, Łazarczyk Marzena, Gorzałczyński Michał, Skiba Dominik, Wolińska Renata, Bujalska-Zadrożny Magdalena, Lutfy Kabirullah, Sadowski Bogdan, Sacharczuk Mariusz

机构信息

Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, Poland.

Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, 02-091 Warsaw, Poland.

出版信息

Brain Sci. 2021 May 13;11(5):622. doi: 10.3390/brainsci11050622.

DOI:10.3390/brainsci11050622
PMID:34067974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8152237/
Abstract

The development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood-brain barrier permeability, to determine the influence of cross-fostering of these lines raised by surrogate mothers on ethanol consumption and development of depressive-like behaviors. We also investigated ethanol drinking by biological parents or surrogate mothers. Furthermore, we investigated whether these parental changes would alter the effect of naloxone on ethanol intake and depressive-like behaviors in offspring. Our results reveal that cross-fostering of HA and LA raised by surrogate mothers has a greater impact on depressive-like behaviors than ethanol consumption. Ethanol intake by biological parents substantially affected depressive-like behaviors and ethanol consumption in offspring. Moreover, ethanol intake by biological parents or an adoptive mother modified the effect of naloxone on ethanol consumption and preference and depressive-like behaviors in the HA offspring only. Together, these results indicate that cross-fostering differentially affects the effect of naloxone on alcohol consumption and the development of depression.

摘要

酒精依赖和抑郁症的发展由多种遗传和环境因素决定。在本研究中，我们使用了高镇痛（HA）和低镇痛（LA）小鼠品系，它们具有不同的内源性阿片系统活性和不同的血脑屏障通透性，以确定由代孕母亲抚养的这些品系的交叉寄养对乙醇消耗和抑郁样行为发展的影响。我们还研究了亲生父母或代孕母亲的乙醇饮用情况。此外，我们研究了这些亲代变化是否会改变纳洛酮对后代乙醇摄入量和抑郁样行为的影响。我们的结果表明，由代孕母亲抚养的HA和LA的交叉寄养对抑郁样行为的影响比对乙醇消耗的影响更大。亲生父母的乙醇摄入量对后代的抑郁样行为和乙醇消耗有显著影响。此外，亲生父母或养母的乙醇摄入量仅改变了纳洛酮对HA后代乙醇消耗、偏好和抑郁样行为的影响。总之，这些结果表明交叉寄养对纳洛酮对酒精消耗和抑郁症发展的影响有不同的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/19db2d6b39fe/brainsci-11-00622-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/baf7ecf1dece/brainsci-11-00622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/fceab6eb776d/brainsci-11-00622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/4c2d0580bd16/brainsci-11-00622-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/949e8083c8c5/brainsci-11-00622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/a5bb35fcf873/brainsci-11-00622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/6abbfa33c8f8/brainsci-11-00622-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/4418e3a2eb7e/brainsci-11-00622-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/8305b7cdd26a/brainsci-11-00622-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/520e8535eb39/brainsci-11-00622-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/3dc688635c2a/brainsci-11-00622-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/5651dade4b67/brainsci-11-00622-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/36f6df4b2102/brainsci-11-00622-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/19db2d6b39fe/brainsci-11-00622-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/baf7ecf1dece/brainsci-11-00622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/fceab6eb776d/brainsci-11-00622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/4c2d0580bd16/brainsci-11-00622-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/949e8083c8c5/brainsci-11-00622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/a5bb35fcf873/brainsci-11-00622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/6abbfa33c8f8/brainsci-11-00622-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/4418e3a2eb7e/brainsci-11-00622-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/8305b7cdd26a/brainsci-11-00622-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/520e8535eb39/brainsci-11-00622-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/3dc688635c2a/brainsci-11-00622-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/5651dade4b67/brainsci-11-00622-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/36f6df4b2102/brainsci-11-00622-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef1/8152237/19db2d6b39fe/brainsci-11-00622-g013.jpg

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