Research Institute Japan Bio Products Co., Ltd. Kurume 839-0864, Japan.
Section of Neuromedical Science, Division of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Nutrients. 2021 May 14;13(5):1672. doi: 10.3390/nu13051672.
Human placental extract and animal-derived placental extracts from pigs and horses host a wide range of biological activities. Several placental products are used as medicines, cosmetics, and healthcare substances worldwide. However, the use of placental extracts for neuronal functioning is currently not established because the number of relevant studies is limited. A few previous reports suggested the neuroprotective effect and dendrite genesis effect of placental extract. However, no studies have reported on neurogenesis in placental extracts. Therefore, we aimed to investigate the effects of horse placental extract on neurogenesis, and we examined the protective effect of the extract on the onset of memory disorder. A horse placental extract, JBP-F-02, was used in this study. JBP-F-02 treatment dose-dependently increased the number of neural stem cells and dendrite length under Aβ treatment in primary cultured cortical cells. The oral administration of JBP-F-02 to a 5XFAD mouse model of Alzheimer's disease at a young age significantly prevented the onset of memory dysfunction. This study suggests that the extract has the potential to prevent dementia.
人胎盘提取物和猪、马来源的动物胎盘提取物具有广泛的生物活性。世界范围内，有几种胎盘产品被用作药物、化妆品和保健物质。然而，由于相关研究数量有限，胎盘提取物在神经元功能方面的应用尚未得到证实。一些先前的报告表明胎盘提取物具有神经保护作用和树突发生作用。然而，目前尚无研究报道胎盘提取物具有神经发生作用。因此，我们旨在研究马胎盘提取物对神经发生的影响，并研究提取物对记忆障碍发病的保护作用。本研究使用了马胎盘提取物 JBP-F-02。JBP-F-02 处理可剂量依赖性地增加原代培养皮质细胞中 Aβ处理后的神经干细胞数量和树突长度。在阿尔茨海默病 5XFAD 小鼠模型中，幼年时口服 JBP-F-02 可显著预防记忆功能障碍的发生。本研究提示该提取物具有预防痴呆的潜力。
