Eikelenboom-Schieveld Selma J M, Fogleman James C
Independent Forensic Services LLC, 32796 Edward Dr., Conifer, CO 80433, USA.
Department of Biological Sciences, University of Denver, Denver, CO 80208, USA.
J Pers Med. 2021 May 18;11(5):426. doi: 10.3390/jpm11050426.
From the start of the use of psychoactive prescription medications in the 1950s, physicians reported paradoxical adverse reactions, ranging from newly developing depressions to an increase in existing mood disorders, and extremely violent and bizarre acts of suicide and homicide. It is hypothesized that interactions between the drugs and the enzymes that are primarily responsible for their metabolism (cytochrome P450s) could cause these reactions. In this research, we evaluate statistical associations between CYP450 variant alleles, psychoactive medication, and acts of violence. Fifty-five persons who showed violent behavior or an altered emotional state were investigated for prescribed medication. Fifty-eight volunteers with no history of violence served as the controls. Genetic testing was performed on , , , , and . Statistical analysis was applied to gender, age, number of variant alleles, number and kind of medications, and potential drug-drug, drug-gene, and drug-drug-gene interactions. Four risk factors for developing an altered emotional state and/or acts of violence were identified. There is an association between prescription drugs (most notably antidepressants and other psychoactive medication), having variant alleles for CYP450 genes, and altered emotional states or acts of violence.
自20世纪50年代开始使用精神活性处方药以来，医生们就报告了一些矛盾的不良反应，从新出现的抑郁症到现有情绪障碍的加重，以及极其暴力和怪异的自杀和杀人行为。据推测，药物与主要负责其代谢的酶（细胞色素P450）之间的相互作用可能导致这些反应。在本研究中，我们评估了CYP450变异等位基因、精神活性药物和暴力行为之间的统计关联。对55名表现出暴力行为或情绪状态改变的人进行了处方药调查。58名无暴力史的志愿者作为对照。对CYP1A2、CYP2C9、CYP2C19、CYP2D6和CYP3A4进行了基因检测。对性别、年龄、变异等位基因数量、药物数量和种类以及潜在的药物-药物、药物-基因和药物-药物-基因相互作用进行了统计分析。确定了情绪状态改变和/或暴力行为发生的四个风险因素。处方药（最显著的是抗抑郁药和其他精神活性药物）、具有CYP450基因的变异等位基因与情绪状态改变或暴力行为之间存在关联。
