一些尿嘧啶核苷作为有前景的抗单纯疱疹病毒1型药物的合成与评价

Awad Samir Mohamed, Ali Shima Mahmoud, Mansour Yara Essam, Fatahala Samar Said

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.

Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.

Molecules. 2021 May 18;26(10):2988. doi: 10.3390/molecules26102988.

Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir.

由于单纯疱疹病毒1型（HSV-1）感染非常普遍，已经研发了几种抗病毒药物来治疗它，其中包括尿嘧啶核苷。然而，目前的药物存在严重的副作用和耐药性等主要问题。在此，我们展示了一些新合成的环状和非环状尿嘧啶核苷，与阿昔洛韦相比，它们对HSV-1显示出非常有前景的活性。