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对接受无创呼吸支持的重症细支气管炎患者喂养方式及并发症的回顾性分析

A Retrospective Analysis of Feeding Practices and Complications in Patients with Critical Bronchiolitis on Non-Invasive Respiratory Support.

作者信息

Lenihan Ariann, Ramos Vannessa, Nemec Nichole, Lukowski Joseph, Lee Junghyae, Kendall K M, Mahapatra Sidharth

机构信息

Children's Hospital and Medical Center, Omaha, NE 68114, USA.

Boys Town National Research Hospital, Omaha, NE 68010, USA.

出版信息

Children (Basel). 2021 May 18;8(5):410. doi: 10.3390/children8050410.

Abstract

Limited data exist regarding feeding pediatric patients managed on non-invasive respiratory support (NRS) modes that augment oxygenation and ventilation in the setting of acute respiratory failure. We conducted a retrospective cohort study to explore the safety of feeding patients managed on NRS with acute respiratory failure secondary to bronchiolitis. Children up to two years old with critical bronchiolitis managed on continuous positive airway pressure, bilevel positive airway pressure, or RAM cannula were included. Of the 178 eligible patients, 64 were reportedly nil per os (NPO), while 114 received enteral nutrition (EN). Overall equivalent in severity of illness, younger patients populated the EN group, while the NPO group experienced a higher incidence of intubation. Duration of stay in the pediatric intensive care unit and non-invasive respiratory support were shorter in the NPO group, though intubation eliminated the former difference. Within the EN group, ninety percent had feeds initiated within 48 h and 94% reached full feeds within 7 days of NRS initiation, with an 8% complication and <1% aspiration rate. Reported complications did not result in escalation of respiratory support. Notably, a significant improvement in heart rate and respiratory rate was noted after feeds initiation. Taken together, our study supports the practice of early enteral nutrition in patients with critical bronchiolitis requiring NRS.

摘要

关于在急性呼吸衰竭情况下使用增强氧合和通气的无创呼吸支持(NRS)模式管理的儿科患者的喂养数据有限。我们进行了一项回顾性队列研究,以探讨在因细支气管炎继发急性呼吸衰竭而接受NRS管理的患者中喂养的安全性。纳入了使用持续气道正压通气、双水平气道正压通气或RAM套管进行管理的两岁以下重症细支气管炎患儿。在178名符合条件的患者中,据报告64名患者禁食(NPO),而114名患者接受肠内营养(EN)。总体疾病严重程度相当,EN组患者年龄较小,而NPO组插管发生率较高。NPO组在儿科重症监护病房的住院时间和无创呼吸支持时间较短,不过插管消除了前一差异。在EN组中,90%的患者在48小时内开始喂养,94%的患者在NRS开始后7天内达到全量喂养,并发症发生率为8%,误吸率<1%。报告的并发症未导致呼吸支持升级。值得注意的是,开始喂养后心率和呼吸频率有显著改善。综上所述,我们的研究支持对需要NRS的重症细支气管炎患者进行早期肠内营养的做法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93ab/8157845/f4b7d1548b63/children-08-00410-g001.jpg

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