Robertson C L
West J Med. 1988 Jul;149(1):111-2.
Mortality from breast cancer may be reduced by more than 10,000 deaths per year in this country if the recommendations for screening all asymptomatic women older than 40 years for breast cancer, issued in 1982 by the American Cancer Society and the American College of Radiology, are followed. Compliance with those recommendations six years later is poor, even in well-to-do, medically served populations, primarily because of poor compliance by physicians. Radiation risk is an often-cited concern, although it has been shown to be an insignificant factor in breast cancer screening. High cost, also cited as a concern, is less of a problem-the charges for mammography having declined steeply in the past few years. At the current price levels, it makes financial and humanitarian sense to provide screening rather than terminal care for metastatic breast cancer. The third concern cited by physicians, that of diagnostic accuracy, must be addressed by a careful and accurate statistical description of the results of each screening program. Sensitivity of more than 80% with positive predictive values of about a third can be achieved.
如果遵循美国癌症协会和美国放射学会1982年发布的对所有40岁以上无症状女性进行乳腺癌筛查的建议,该国每年因乳腺癌导致的死亡人数可能会减少1万多人。六年后对这些建议的遵守情况很差,即使在富裕且能获得医疗服务的人群中也是如此,主要原因是医生的遵守情况不佳。辐射风险是一个经常被提及的担忧,尽管在乳腺癌筛查中它已被证明是一个微不足道的因素。同样被视为担忧的高成本问题已不那么突出——过去几年乳房X光检查的费用大幅下降。按照当前的价格水平,提供筛查而非转移性乳腺癌的终末期护理在经济和人道方面都有意义。医生提到的第三个担忧,即诊断准确性问题,必须通过对每个筛查项目的结果进行仔细准确的统计描述来解决。可以实现超过80%的敏感度和约三分之一的阳性预测值。