Ton Mimi, Widener Michael J, James Peter, VoPham Trang
Department of Epidemiology, University of Washington School of Public Health, 3980 15th Ave NE, Seattle, WA 98195, USA.
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.
Int J Environ Res Public Health. 2021 May 27;18(11):5740. doi: 10.3390/ijerph18115740.
Research into the potential impact of the food environment on liver cancer incidence has been limited, though there is evidence showing that specific foods and nutrients may be potential risk or preventive factors. Data on hepatocellular carcinoma (HCC) cases were obtained from the Surveillance, Epidemiology, and End Results (SEER) cancer registries. The county-level food environment was assessed using the Modified Retail Food Environment Index (mRFEI), a continuous score that measures the number of healthy and less healthy food retailers within counties. Poisson regression with robust variance estimation was used to calculate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for the association between mRFEI scores and HCC risk, adjusting for individual- and county-level factors. The county-level food environment was not associated with HCC risk after adjustment for individual-level age at diagnosis, sex, race/ethnicity, year, and SEER registry and county-level measures for health conditions, lifestyle factors, and socioeconomic status (adjusted IRR: 0.99, 95% CI: 0.96, 1.01). The county-level food environment, measured using mRFEI scores, was not associated with HCC risk.
尽管有证据表明特定食物和营养素可能是潜在的风险或预防因素，但关于食物环境对肝癌发病率潜在影响的研究一直有限。肝细胞癌（HCC）病例的数据来自监测、流行病学和最终结果（SEER）癌症登记处。县级食物环境使用改良零售食物环境指数（mRFEI）进行评估，mRFEI是一个连续评分，用于衡量各县内健康和不太健康的食品零售商数量。采用稳健方差估计的泊松回归来计算mRFEI评分与HCC风险之间关联的发病率比（IRR）和95%置信区间（CI），并对个体和县级因素进行调整。在对个体层面的诊断年龄、性别、种族/民族、年份、SEER登记处以及县级健康状况、生活方式因素和社会经济地位进行调整后，县级食物环境与HCC风险无关（调整后的IRR：0.99，95%CI：0.96，1.01）。使用mRFEI评分衡量的县级食物环境与HCC风险无关。
