Winzer M, Gilliar U
Klinik für Dermatologie und Venerologie der Medizinischen Universität zu Lübeck.
Z Hautkr. 1988 Jun 15;63(6):517-20.
10 specimens taken from oral hairy leukoplakia were compared to 8 histological preparations from hairy tongue. We found 9 criteria helpful concerning the histopathologic differential diagnosis of these entities. Oral hairy leukoplakia shows a gently papillated surface, a prominent horny layer with confluent bacterial overgrowth, and ballooned epithelial cells with a distinct perinuclear halo in a bandlike arrangement. Hairy tongue, in contrast, grows exophytically with a digitiform surface, the horny layer is rather thin, and the microorganisms are confined to the ends of the digitations; the ballooned epithelial cells show pale cytoplasm. Considering the growing incidents of HIV infection, the dermatologist should be familiar with the characteristics of oral hairy leukoplakia and its histopathological differential diagnosis.
取自口腔毛状白斑的10个标本与来自毛舌的8个组织学制剂进行了比较。我们发现9条标准有助于这些病变的组织病理学鉴别诊断。口腔毛状白斑表现为表面轻度乳头状，角质层突出，有融合的细菌过度生长，以及带状排列的气球样上皮细胞，其核周有明显晕圈。相比之下，毛舌呈外生性生长，表面呈指状，角质层相当薄，微生物局限于指状突起的末端；气球样上皮细胞显示胞质淡染。鉴于HIV感染发生率不断上升，皮肤科医生应熟悉口腔毛状白斑的特征及其组织病理学鉴别诊断。
