Kruse W, Köhler J, Oster P, Schlierf G
Krankenhaus Bethanien, Heidelberg.
Z Gerontol. 1988 May-Jun;21(3):164-8.
In 196 hospitalized geriatric patients, drug prescriptions were assessed for potential drug interactions. Potential drug interactions were identified in 5.4% of 2,177 prescriptions. The risk increased with the number of prescribed drugs. Antipsychotics, tranquilizers, hypnotics, diuretics, cardiac glycosides and centrally acting analgetics were involved in more than 70% of potential interactions. Risks of potential drug interactions can be reduced by a reduction in drugs prescribed.
在196名住院老年患者中,对药物处方进行了潜在药物相互作用评估。在2177张处方中,有5.4%被识别出存在潜在药物相互作用。风险随着所开药物数量的增加而上升。超过70%的潜在相互作用涉及抗精神病药、镇静剂、催眠药、利尿剂、强心苷和中枢性镇痛药。减少所开药物的数量可以降低潜在药物相互作用的风险。