Venbrocks R, Nicolas V, Rüther W, Clauss G
Orthopädische Universitätsklinik Bonn.
Z Orthop Ihre Grenzgeb. 1988 Mar-Apr;126(2):190-4. doi: 10.1055/s-2008-1044891.
This paper documents a prospective study of the serial changes in the MRI appearances of the intervertebral disc after chemonucleolysis with chymopapain. After chemonucleolysis the mass of the disc prolaps had not changed. But there was a diminution of water content. The authors suggest that chemonucleolysis induces changes in the disc that may be comparable to degenerative processes. In consequence it may be of no use to carry out the chemonucleolysis in those cases, in which degenerative changes are already present in MR-imaging.
本文记录了木瓜凝乳蛋白酶化学髓核溶解术后椎间盘MRI表现的系列变化的前瞻性研究。化学髓核溶解术后椎间盘突出物的大小没有改变，但含水量减少。作者认为，化学髓核溶解术可引起椎间盘的变化，这些变化可能与退变过程相似。因此，在MRI成像中已有退变改变的病例中进行化学髓核溶解术可能没有用处。
