Mesrogli M, Maas D H, Schneider J
Frauenklinik der Medizinischen Hochschule Hannover.
Zentralbl Gynakol. 1988;110(9):555-61.
To evaluate the diagnostic value of Early Pregnancy Factor (EPF) measurements in infertile patients, we performed a modified rosette inhibition test in 58 women after follicular stimulation and/or homologous artificial insemination (AIH). The patients were grouped according to the main diagnosis as cervical hostility, poor semen quality, and anovulation. While the overall fertilization rate in our patients was 39.6%, which is considerably lower than in comparable studies of fertile women, the pregnancy rates per EPF positive cycle in the various groups were 25.0%, 30.8%, and 50.5%, respectively. As the process of fertilization can be detected by EPF measurement within 48 h after ovulation, a distinction can be made between failure of fertilization and of implantation. Thus, a valuable diagnostic tool has become available for treatment of infertile patients.
为评估早期妊娠因子（EPF）检测对不孕患者的诊断价值，我们对58名经卵泡刺激和/或同种人工授精（AIH）后的女性进行了改良的玫瑰花结抑制试验。患者根据主要诊断分为宫颈因素、精液质量差和无排卵。虽然我们患者的总体受精率为39.6%，明显低于对有生育能力女性的类似研究，但各亚组中每个EPF阳性周期的妊娠率分别为25.0%、30.8%和50.5%。由于排卵后48小时内可通过EPF检测受精过程，因此可区分受精失败和着床失败。因此，一种有价值的诊断工具已可用于不孕患者的治疗。
