Straube W, Römer T, Zeenni L, Loh M
Klinikum Ernst-Moritz-Arndt-Universität Greifswald.
Zentralbl Gynakol. 1995;117(1):32-4.
The early pregnancy factor (EPF) seems to be very helpful in clinical applications such as early detection of pregnancy, differential diagnosis of failure of fertilization or implementation and prognosis of a fertilized ovum. Our purpose was to investigate the diagnostic value of single and serial measurement of EPF, especially in the differential diagnosis of abortion and extrauterine pregnancy. Women with a history of 6-16 weeks amenorrhoea with/without vaginal bleeding were included in the prospective study. The EPF-test system was carried out by means of the rosette inhibition method. EPF proved to be always positive in normal pregnant women and always negative in nonpregnant controls. In case of threatened abortion the prognosis was good, when the EPF values were positive, and poor when they became negative. Patients suffering from spontaneous and missed abortion mostly showed negative EPF-values. This was also true in ectopic pregnancies. The sensitivity and specificity of EPF-test system were 83%. The positive predictive value was observed to be 54% and the negative predictive value 95%. The EPF as an early embryonic signal may be a suitable parameter for the clinical use detecting pregnancy disturbances very early.
早期妊娠因子（EPF）似乎在诸如妊娠早期检测、受精或着床失败的鉴别诊断以及受精卵预后等临床应用中非常有用。我们的目的是研究单次和连续测量EPF的诊断价值，尤其是在流产和宫外孕的鉴别诊断中。有6至16周闭经史且有/无阴道出血的女性被纳入前瞻性研究。EPF检测系统采用玫瑰花结抑制法进行。EPF在正常孕妇中始终呈阳性，在非妊娠对照组中始终呈阴性。在先兆流产的情况下，EPF值为阳性时预后良好，变为阴性时预后不良。自然流产和稽留流产患者大多显示EPF值为阴性。宫外孕患者也是如此。EPF检测系统的敏感性和特异性为83%。观察到阳性预测值为54%，阴性预测值为95%。EPF作为一种早期胚胎信号，可能是临床早期检测妊娠异常的合适参数。
