College of Physics, Sichuan University, Chengdu, China.
School of Chemical Engineering, Sichuan University, Chengdu, China.
J Biomater Appl. 2021 Nov;36(5):757-771. doi: 10.1177/08853282211020158. Epub 2021 Jun 1.
In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse. The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail. The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements. The results indicated that Pul promoted the hydration formation of DCPD, and interface bonding occurred between Pul and DCPD. With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
在这项工作中，通过一水磷酸氢钙和氧化钙的水合反应，制备了一种具有独特生物降解能力的磷酸二氢钙（DCPD）骨水泥，该水合反应与聚右旋糖酐（Pul）相结合，Pul 是一种无毒、生物相容、粘性和水溶性多糖，已成功用于改善 DCPD 骨水泥的缺陷，特别是其快速凝固、脆弱的机械性能和易塌陷的问题。还详细研究了 Pul 的不同含量对 DCPD 结构和性能的影响。通过 X 射线衍射、傅里叶变换红外光谱、扫描电子显微镜、紫外可见吸收、X 射线光电子能谱分析和流变性能测试对改性水泥进行了表征。结果表明，Pul 促进了 DCPD 的水化形成，并且 Pul 与 DCPD 之间发生了界面键合。随着 Pul 含量的增加，DCPD 骨水泥的凝固时间从 2.6 分钟增加到 42.3 分钟，抗压强度从 0 MPa 增加到 20.4 MPa，由于强界面键合，抗塌陷能力也得到了提高，这意味着与未改性的 DCPD 骨水泥相比，经 Pul 改性的 DCPD 骨水泥在非承重骨再生医学领域具有更好的应用潜力。
