Molecular Epidemiology and Biotechnology Laboratory/Rodolfo Albino University Laboratory - Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.
Postgraduate Program in Science and Biotechnology - Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.
Nat Prod Res. 2022 May;36(10):2643-2647. doi: 10.1080/14786419.2021.1915306. Epub 2021 Jun 2.
is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 µg/mL, the extract showed bactericidal activity against a clinical multidrug-resistant strain (HU25) and also inhibited biofilm formation at 1/2xMIC (confirmed by SEM) and 1/4xMIC. The extract was also proportionally active against 6 h-preformed biofilm to its concentration (1/2xMIC, 1/4xMIC, value ≤ 0.05). These promising results make extract a strong candidate to treat infections, including anti-biofilm therapy.
被认为是人类中最常见的机会性病原体，能够形成生物膜，增加抗生素耐药性的机会，并导致多种慢性疾病。生物多样性是寻找针对这些微生物的新型药物的灵感来源。迄今为止， 属提取物作为一种抗菌剂已经被证明对革兰氏阳性和革兰氏阴性细菌有效。在这项研究中，我们观察到，在 4μg/mL 之前， 提取物对临床耐多药 株（HU25）表现出杀菌活性，并且在 1/2xMIC（通过 SEM 证实）和 1/4xMIC 时也抑制生物膜形成。提取物对 6 小时形成的生物膜也具有浓度依赖性活性（1/2xMIC、1/4xMIC、 值≤0.05）。这些有希望的结果使 提取物成为治疗 感染的有力候选物，包括抗生物膜治疗。
