Departamento de Cardiologia, Adıyaman University Training and Research Hospital, Adıyaman - Turquia.
Gaziantep University Medicine Faculty, Departamento de Cardiologia, Gaziantep - Turquia.
Arq Bras Cardiol. 2021 Sep;117(3):503-510. doi: 10.36660/abc.20200492.
The beneficial effects of Elabela on the cardiovascular system have been shown in studies.
To compare serum Elabela levels of chronic total occlusion (CTO) patients with control patients with normal coronary arteries, and to investigate whether there is a correlation with collateral development.
The study was planned cross-sectionally and prospectively. Fifty patients (28.0% female, mean age 61.6±7.3years) with CTO in at least one coronary vessel and 50 patients (38% female, mean age 60,7±6.38 years) with normal coronary arteries were included in the study. Patients in the CTO group were divided into two groups as Rentrop 0-1, those with weak collateral development, and Rentrop 2-3 with good collateral development. In addition to the age, sex, demographic characteristics and routine laboratory tests of the patients, Elabela levels were measured.
Demographic characteristics and laboratory values were similar in both groups. While the mean NT-proBNP and troponin were higher in the CTO group, the Elabela mean was lower (p <0.05 for all). In the multivariate regression analysis, NT-proBNP and Elabela levels were found to be independent predictors for CTO. Also, Elabela level was found to be statistically higher in Rentrop class 2-3 patients compared to Rentrop class 0-1 patients (p<0.05).
In our study, we showed that the average Elabela level was low in CTO patients compared to normal patients. In addition, we found the level of Elabela to be lower in patients with weak collateral development compared to patients with good collateral development. (Arq Bras Cardiol. 2021; [online].ahead print, PP.0-0).
已有研究表明 Elabela 对心血管系统有有益作用。
比较慢性完全闭塞（CTO）患者和正常冠状动脉患者的血清 Elabela 水平，并探讨其与侧支循环发展的相关性。
该研究为前瞻性、横断面研究。纳入至少一支冠状动脉存在 CTO 的 50 例患者（28.0%为女性，平均年龄 61.6±7.3 岁）和 50 例正常冠状动脉患者（38%为女性，平均年龄 60.7±6.38 岁）。CTO 组患者根据Rentrop 分级分为侧支循环弱组（Rentrop 0-1 级）和侧支循环强组（Rentrop 2-3 级）。除了患者的年龄、性别、人口统计学特征和常规实验室检查外，还测量了 Elabela 水平。
两组患者的人口统计学特征和实验室值相似。虽然 CTO 组的平均 NT-proBNP 和肌钙蛋白较高，但 Elabela 平均值较低（所有比较均 p<0.05）。在多变量回归分析中，NT-proBNP 和 Elabela 水平被发现是 CTO 的独立预测因子。此外，与 Rentrop 0-1 级患者相比，Rentrop 2-3 级患者的 Elabela 水平更高（p<0.05）。
在本研究中，我们发现与正常患者相比，CTO 患者的平均 Elabela 水平较低。此外，我们发现侧支循环较弱的患者的 Elabela 水平低于侧支循环较强的患者。（Arq Bras Cardiol. 2021; [online]. ahead print, PP.0-0）。
