Farias Andrezza Duarte, Lima Kenio Costa, Oliveira Yonara Monique da Costa, Leal Adriana Amorim de Farias, Martins Rand Randall, Freitas Claudia Helena Soares de Morais
Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal do Rio Grande do Norte (UFRN). Av. Senador Salgado Filho 3000, Lagoa Nova. 59078-900 Natal RN Brasil.
Universidade Federal de Campina Grande. Cuité PB Brasil.
Cien Saude Colet. 2021 May;26(5):1781-1792. doi: 10.1590/1413-81232021265.04532021.
The elderly population is vulnerable to the risks of the use of medications, especially those considered potentially inappropriate medications (PIMs), in which the risks outweigh the benefits. The study sought to evaluate the PIMs prescribed in Primary Health Care (PHC) and associated factors. A cross-sectional, analytical study was carried out from March to December 2019 in PHC in Campina Grande, Paraíba, through interviews with 458 elderly individuals. The independent variables included socioeconomic characteristics, health status and the use of medications, and the outcome was classified as PIM by the Brazilian Consensus on Potentially Inappropriate Medications. There was a prescription of at least one PIM for 44.8% of the elderly and the majority affecting the Central Nervous System (54.4%). In the adjusted model, depression (PR=2.01; 95%CI 1.59-2.55), using other medications in addition to those prescribed (PR=1.36; 95%CI 1.08-1.72) and polypharmacy (PR=1.80; 95%CI 1.40-2.33) remained an associated factor, and self-reporting systemic arterial hypertension became a protective factor (PR=0.65; 95%CI 0.49-0.87). This reveals the need for actions to monitor closely the use of PIMs by the elderly to ensure access in conjunction with safety.
老年人群体易受用药风险影响，尤其是那些被认为有潜在不适当用药（PIM）风险的药物，这类药物风险大于益处。该研究旨在评估初级卫生保健（PHC）中开具的PIM及其相关因素。2019年3月至12月，在帕拉伊巴州大坎皮纳的初级卫生保健机构开展了一项横断面分析研究，对458名老年人进行了访谈。自变量包括社会经济特征、健康状况和用药情况，结局根据巴西潜在不适当用药共识被分类为PIM。44.8%的老年人至少开具了一种PIM，其中大多数影响中枢神经系统（54.4%）。在调整模型中，抑郁症（PR = 2.01；95%CI 1.59 - 2.55）、除所开药物外还使用其他药物（PR = 1.36；95%CI 1.08 - 1.72）和多重用药（PR = 1.80；95%CI 1.40 - 2.33）仍是相关因素，而自我报告患有系统性动脉高血压则成为保护因素（PR = 0.65；95%CI 0.49 - 0.87）。这表明需要采取行动密切监测老年人使用PIM的情况，以确保在安全的前提下用药。
