De Clercq Pauline, Geerts Anja, Van Vlierberghe Hans, Verhelst Xavier
Department of Gastroenterology and Hepatology, Ghent University Hospital, Gent, Belgium.
Ghent Liver Research Center, Ghent University, Gent, Belgium.
Hepatol Res. 2021 Jul;51(7):750-757. doi: 10.1111/hepr.13668. Epub 2021 Jun 2.
Acute liver failure (ALF) is a rare but potential lethal condition characterized by the sudden development of jaundice, coagulopathy and hepatic encephalopathy in patients without underlying liver disease. In selected patients, emergency liver transplantation is required. Selection of these patients is based on clinical criteria such as the Kings College Criteria (KCC) or the Clichy criteria.
The aim of this work is to provide an overview of potential biomarkers that could improve the prognostic value of KCC.
Several promising biomarkers involved in related pathophysiological processes have been identified. Some could be as stand-alone biomarkers; however, the best prognostic values have been observed in the combination of biomarkers with current models. Among these, the ALFSG Index that combines clinical parameters and circulating blood levels of CK18 claims a higher prognostic value than KCC.
In this review, all potential biomarkers for ALF have been summarized to give an overview of the work performed over the last years, and a glimpse of what to expect in this field in the coming years.
急性肝衰竭（ALF）是一种罕见但潜在致命的病症，其特征是在无基础肝病的患者中突然出现黄疸、凝血功能障碍和肝性脑病。对于部分患者，需要进行紧急肝移植。这些患者的选择基于临床标准，如国王学院标准（KCC）或克利希标准。
本研究旨在概述可能提高KCC预后价值的潜在生物标志物。
已鉴定出几种参与相关病理生理过程的有前景的生物标志物。有些可作为独立的生物标志物；然而，生物标志物与现有模型联合使用时观察到最佳的预后价值。其中，结合临床参数和CK18循环血水平的ALFSG指数比KCC具有更高的预后价值。
在本综述中，总结了ALF的所有潜在生物标志物，以概述过去几年所开展的工作，并展望未来几年该领域的发展。
