Takahashi E S
School of Optometry, University of Alabama, Birmingham.
Am J Optom Physiol Opt. 1988 May;65(5):331-6. doi: 10.1097/00006324-198805000-00004.
Dopaminergic neurons have been directly visualized in the flat mount cat retina with an immunohistochemical technique that uses antisera directed to the enzyme tyrosine hydroxylase. In a previous study, three specific neuronal populations--amacrine cells, displaced amacrine (DA) cells, and interplexiform (IP) cells--were identified on the basis of morphology in the flat mount retina. The present study incorporates three-dimensional computer reconstructions and differences in the frequency distributions of some area to support the original cell classification. The three neuronal populations differ in cell numbers and spatial distributions in the retina; quantitative comparison of two cat retinas shows that the total numbers of cells and the spatial distributions of the three cell populations are consistent between retinas. These results suggest that a single neurotransmitter can serve different functions in modifying signals and flow of visual information within the neural networks of the retina.
利用针对酪氨酸羟化酶的抗血清的免疫组织化学技术，在扁平猫视网膜中直接观察到了多巴胺能神经元。在先前的一项研究中，根据扁平视网膜中的形态学特征，鉴定出了三种特定的神经元群体——无长突细胞、移位无长突（DA）细胞和网间（IP）细胞。本研究结合了三维计算机重建以及一些区域频率分布的差异，以支持最初的细胞分类。这三种神经元群体在视网膜中的细胞数量和空间分布有所不同；对两只猫视网膜的定量比较表明，视网膜之间这三种细胞群体的总数和空间分布是一致的。这些结果表明，单一神经递质在视网膜神经网络内修饰视觉信息的信号和流动方面可以发挥不同的功能。
