Department of Ophthalmology, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon, Republic of Korea.
Department of Pharmacology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
PLoS One. 2021 Jun 2;16(6):e0252530. doi: 10.1371/journal.pone.0252530. eCollection 2021.
To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group.
A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month.
At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5-6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3-3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001).
The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO.
与视网膜分支静脉阻塞（BRVO）患者和正常对照组相比，研究中央性视网膜静脉阻塞（CRVO）患者房水中内皮素-1（ET-1）的浓度。
本前瞻性研究共纳入 80 例患者，包括 15 例 CRVO 患者、20 例 BRVO 患者和 45 例行白内障手术且无伴发眼部疾病的患者。在玻璃体内注射贝伐单抗（IVB）前和 1 个月后采集房水 ET-1 水平。
基线时，CRVO 组房水中 ET-1 的平均水平为 12.7±3.6pg/ml，BRVO 组为 8.0±2.3pg/ml，对照组为 2.0±0.9pg/ml（P<0.001）。IVB 后，CRVO 组房水中 ET-1 的平均水平为 3.4±1.9pg/ml（0.5-6.9pg/ml），BRVO 组为 1.8±1.0pg/ml（0.3-3.2pg/ml）（P=0.008）。CRVO 组和 BRVO 组的房水中 ET-1 平均水平均显著降低（P<0.001）。
CRVO 患者房水中 ET-1 水平明显高于 BRVO 患者和对照组。IVB 后，CRVO 组和 BRVO 组的平均水平均显著降低。
