UCLA at Kern Medical Center, Bakersfield, CA, USA.
Ross University, Bridgetown, Barbados.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211021696. doi: 10.1177/23247096211021696.
Hemophagocytic lymphohistiocytosis (HLH) in acute human immunodeficiency virus (HIV) patients has been scarcely reported in the English literature. To the best of our knowledge, only 12 cases have been described. We present a case of a 27-year-old male with no past medical history who was admitted with a new-onset headache, fever, night sweats, and chills. Further laboratory tests revealed transaminitis, leukopenia, thrombocytopenia, positive HIV antigen/antibody test, and markedly elevated ferritin levels, which promoted our suspicion of HLH. This case demonstrates HLH as an unusual presentation of HIV during its seroconversion stage. This report adds a rare disease process to the available literature, and we emphasize that markedly elevated ferritin levels in acute HIV patients should raise suspicion toward a diagnosis of HLH.
噬血细胞性淋巴组织细胞增生症（HLH）在急性人类免疫缺陷病毒（HIV）患者中在英文文献中鲜有报道。据我们所知，仅有 12 例病例被描述。我们报告了一例 27 岁男性患者，无既往病史，因新发头痛、发热、盗汗和寒战入院。进一步的实验室检查显示肝功能异常、白细胞减少、血小板减少、HIV 抗原/抗体检测阳性和铁蛋白水平显著升高，这促使我们怀疑为 HLH。该病例表明 HLH 是 HIV 血清转换期的一种不常见表现。本报告为现有文献增加了一种罕见的疾病过程，我们强调急性 HIV 患者铁蛋白水平显著升高应提示 HLH 的诊断。
