中国儿童中多态性与胶质瘤易感性的关联
Association of Polymorphisms with Glioma Susceptibility in Chinese Children.
作者信息
Zhou Jingying, Wang Pan, Zhang Ran, Huang Xiaokai, Dai Hanqi, Yuan Li, Ruan Jichen
机构信息
Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
Sydney School of Public Health, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
出版信息
Pharmgenomics Pers Med. 2021 May 25;14:601-607. doi: 10.2147/PGPM.S310780. eCollection 2021.
BACKGROUND
Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. is a proto-oncogene with increased expression in various malignancies.
METHODS
We explored the association of polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan.
RESULTS
Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13-2.58, = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26-7.74, = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25-2.73, = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05-6.33, = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2-3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31-2.84, = 0.001) relative to those with 0-1 risk genotype.
CONCLUSION
rs6581658 A>G is associated with glioma susceptibility in Chinese children.
背景
胶质瘤是儿童恶性中枢神经系统肿瘤，预后较差。 是一种原癌基因，在多种恶性肿瘤中表达增加。
方法
我们采用病例对照研究（191例病例，248例对照）探讨了中国儿童 基因多态性与胶质瘤易感性的关联。使用基于PCR的TaqMan技术对单核苷酸多态性（rs6581658 A>G；rs8756 A>C；rs968697 T>C）进行基因分型。
结果
胶质瘤易感性增加与rs6581658 A>G相关；与AA基因型携带者相比，AG（调整后的比值比（OR）=1.71，95%置信区间（CI）=1.13-2.58， =0.010）或GG（调整后的OR =3.12，95%CI =1.26-7.74， =0.014）基因型携带者的胶质瘤风险显著升高。与AA基因型相比，rs6581658 AG/GG（调整后的OR =1.85，95%CI =1.25-2.73， =0.002）和AA/GG（调整后的OR =2.58，95%CI =1.05-6.33， =0.038）基因型与胶质瘤风险增加相关。与具有0-1个风险基因型的受试者相比，具有2-3个风险基因型的受试者风险显著升高（调整后的OR =1.93，95%CI =1.31-2.84， =0.001）。
结论
rs6581658 A>G与中国儿童的胶质瘤易感性相关。
Zotero 插件