Quispel Rutger, Schutz Hannah M, Hallensleben Nora D, Bhalla Abha, Timmer Robin, van Hooft Jeanin E, Venneman Niels G, Erler Nicole S, Veldt Bart J, van Driel Lydi M J W, Bruno Marco J
Department of Gastroenterology and Hepatology, Reinier de Graaf Hospital, Delft, Netherlands.
Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands.
Endosc Int Open. 2021 Jun;9(6):E911-E917. doi: 10.1055/a-1452-8919. Epub 2021 May 27.
Endoscopic ultrasonography (EUS) is a tool widely used to diagnose bile duct lithiasis. In approximately one out of five patients with positive findings at EUS, sludge is detected in the bile duct instead of stones. The objective of this study was to establish the agreement among endosonographers regarding: 1. presence of common bile duct (CBD) stones, microlithiasis and sludge; and 2. the need for subsequent treatment. 30 EUS videos of patients with an intermediate probability of CBD stones were evaluated by 41 endosonographers. Experience in EUS and endoscopic retrograde cholangiopancreatography, and the endosonographers' type of practices were recorded. Fleiss' kappa statistics were used to quantify the agreement. Associations between levels of experience and both EUS ratings and treatment decisions were investigated using mixed effects models. A total of 1230 ratings and treatment decisions were evaluated. The overall agreement on EUS findings was fair (Fleiss' κ 0.32). The agreement on presence of stones was moderate (κ 0.46). For microlithiasis it was fair (κ 0.25) and for sludge it was slight (κ 0.16). In cases with CBD stones there was an almost perfect agreement for the decision to subsequently perform an ERC + ES. In case of presumed microlithiasis or sludge an ERC was opted for in 78 % and 51 % of cases, respectively. Differences in experience and types of practice appear unrelated to the agreement on both EUS findings and the decision for subsequent treatment. There is only slight agreement among endosonographers regarding the presence of bile duct sludge. Regarding the need for subsequent treatment of bile duct sludge there is no consensus.
内镜超声检查(EUS)是一种广泛用于诊断胆管结石的工具。在EUS检查结果呈阳性的患者中,约五分之一的患者胆管内检测到的是胆泥而非结石。本研究的目的是确定内镜超声检查医师在以下方面的一致性:1. 胆总管(CBD)结石、微结石和胆泥的存在情况;2. 是否需要后续治疗。41位内镜超声检查医师对30例具有中等CBD结石可能性患者的EUS视频进行了评估。记录了他们在EUS和内镜逆行胰胆管造影方面的经验以及内镜超声检查医师的执业类型。使用Fleiss卡方统计量来量化一致性。使用混合效应模型研究经验水平与EUS评级及治疗决策之间的关联。
总共评估了1230项评级和治疗决策。对EUS检查结果的总体一致性为中等(Fleiss'κ0.32)。对结石存在情况的一致性为中等(κ0.46)。对微结石的一致性为中等(κ0.25),对胆泥的一致性为轻微(κ0.16)。在存在CBD结石的病例中,对于随后进行内镜逆行胆管造影(ERC)+内镜超声引导下细针穿刺活检(ES)的决策几乎完全一致。在疑似微结石或胆泥的病例中,分别有78%和51%的病例选择了ERC。经验和执业类型的差异似乎与EUS检查结果的一致性以及后续治疗决策无关。内镜超声检查医师在胆管胆泥的存在情况上只有轻微的一致性。关于胆管胆泥是否需要后续治疗,目前尚无共识。