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Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus: Not alarming, but should be taken gravely.未接触过病毒的肾移植受者对SARS-CoV-2 mRNA疫苗BNT162b2的体液反应降低：虽不令人恐慌，但应予以高度重视。
Am J Transplant. 2021 Aug;21(8):2909. doi: 10.1111/ajt.16710. Epub 2021 Jun 18.
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Serological response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients depends on prior exposure to SARS-CoV-2.肾移植受者对新型冠状病毒mRNA疫苗BNT162b2的血清学反应取决于既往对新型冠状病毒的接触情况。
Am J Transplant. 2021 Nov;21(11):3806-3807. doi: 10.1111/ajt.16726. Epub 2021 Jul 10.
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Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus: No cause for alarm.未接触过病毒的肾移植受者对mRNA新冠病毒BNT162b2疫苗的体液免疫反应降低：无需惊慌。
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Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus.肾移植受者在未接触过病毒的情况下，对 mRNA SARS-CoV-2 BNT162b2 疫苗的体液反应降低。
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Kidney transplant recipients vaccinated before transplantation maintain superior humoral response to SARS-CoV-2 vaccine.移植前接种疫苗的肾移植受者对 SARS-CoV-2 疫苗保持优越的体液反应。
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Immunogenicity of SARS-CoV-2 BNT162b2 vaccine in solid organ transplant recipients.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）BNT162b2疫苗在实体器官移植受者中的免疫原性。
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Transplant Proc. 2022 Jul-Aug;54(6):1439-1445. doi: 10.1016/j.transproceed.2022.02.011. Epub 2022 Mar 1.
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Antibody and T-cell response to a third dose of SARS-CoV-2 mRNA BNT162b2 vaccine in kidney transplant recipients.肾移植受者对第三剂SARS-CoV-2 mRNA BNT162b2疫苗的抗体和T细胞反应。
Kidney Int. 2021 Dec;100(6):1337-1340. doi: 10.1016/j.kint.2021.09.014. Epub 2021 Oct 4.

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C1q Binding Ability for Prior Risk Assessment of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.C1q 结合能力可用于评估 ABO 血型不相容的肾移植中急性抗体介导排斥反应的风险。
Transpl Int. 2024 Oct 15;37:13407. doi: 10.3389/ti.2024.13407. eCollection 2024.
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Optimizing SARS-CoV-2 vaccine responses in kidney transplant recipients: an urgent need.优化肾移植受者的 SARS-CoV-2 疫苗反应：当务之急。
Microbiol Spectr. 2024 Jun 4;12(6):e0000424. doi: 10.1128/spectrum.00004-24. Epub 2024 May 15.
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The Cellular and Humoral Immune Response to SARS-CoV-2 Messenger RNA Vaccines Is Significantly Better in Liver Transplant Patients Compared with Kidney Transplant Patients.与肾移植患者相比，肝移植患者对严重急性呼吸综合征冠状病毒2信使核糖核酸疫苗的细胞免疫和体液免疫反应明显更好。
Pathogens. 2023 Jul 5;12(7):910. doi: 10.3390/pathogens12070910.
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Third dose of BNT162b2 improves immune response in liver transplant recipients to ancestral strain but not Omicron BA.1 and XBB.第三剂 BNT162b2 可提高肝移植受者对原始株的免疫应答，但对奥密克戎 BA.1 和 XBB 无效。
Front Immunol. 2023 Jul 3;14:1206016. doi: 10.3389/fimmu.2023.1206016. eCollection 2023.
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Factors That Predict a Sustained Humoral Response to COVID-19 Vaccines in Kidney Transplant Recipients.预测肾移植受者对COVID-19疫苗持续体液免疫反应的因素。
Adv Ther. 2023 Sep;40(9):3956-3970. doi: 10.1007/s12325-023-02580-4. Epub 2023 Jul 1.
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A Scoping Review of the Impact of COVID-19 on Kidney Transplant Patients in the United States.关于2019冠状病毒病对美国肾移植患者影响的范围综述
Cureus. 2023 Mar 3;15(3):e35725. doi: 10.7759/cureus.35725. eCollection 2023 Mar.
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Analysis of Risk Factors for a Low Immune Response to Messenger RNA COVID-19 Vaccine in Kidney Transplant Recipients and Differences Between Second and Third Dose.mRNA 新冠疫苗在肾移植受者中免疫应答较低的危险因素分析及第二、三剂次的差异。
Transplant Proc. 2022 Dec;54(10):2646-2651. doi: 10.1016/j.transproceed.2022.10.032. Epub 2022 Oct 24.
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Cyclosporine A Modulates LSP1 Protein Levels in Human B Cells to Attenuate B Cell Migration at Low O Levels.环孢素A调节人B细胞中LSP1蛋白水平以在低氧水平下减弱B细胞迁移。
Life (Basel). 2022 Aug 22;12(8):1284. doi: 10.3390/life12081284.
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Factors that predict severity of infection and seroconversion in immunocompromised children and adolescents with COVID-19 infection.预测感染新型冠状病毒肺炎（COVID-19）的免疫功能低下儿童和青少年感染严重程度及血清转化的因素。
Front Immunol. 2022 Aug 3;13:919762. doi: 10.3389/fimmu.2022.919762. eCollection 2022.
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COVID-19 and solid organ transplantation: Finding the right balance.COVID-19 与实体器官移植：寻找平衡。
Transplant Rev (Orlando). 2022 Jul;36(3):100710. doi: 10.1016/j.trre.2022.100710. Epub 2022 Jul 4.

本文引用的文献

1
Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus: No cause for alarm.未接触过病毒的肾移植受者对mRNA新冠病毒BNT162b2疫苗的体液免疫反应降低：无需惊慌。
Am J Transplant. 2021 Aug;21(8):2908. doi: 10.1111/ajt.16687. Epub 2021 Jun 4.
2
Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2).医护人员接种两剂 SARS-CoV-2 mRNA 疫苗（BNT162b2）后的早期抗体反应。
Clin Microbiol Infect. 2021 Sep;27(9):1351.e5-1351.e7. doi: 10.1016/j.cmi.2021.05.004. Epub 2021 May 8.
3
Experience with SARS-CoV-2 BNT162b2 mRNA vaccine in dialysis patients.透析患者接种新型冠状病毒2型BNT162b2 mRNA疫苗的经验
Kidney Int. 2021 Jun;99(6):1496-1498. doi: 10.1016/j.kint.2021.04.006. Epub 2021 Apr 20.
4
Humoral Response to the Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis.接受维持性血液透析患者对辉瑞 BNT162b2 疫苗的体液反应。
Clin J Am Soc Nephrol. 2021 Jul;16(7):1037-1042. doi: 10.2215/CJN.03500321. Epub 2021 Apr 6.

Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus: Not alarming, but should be taken gravely.

作者信息

Grupper Ayelet, Katchman Helena

机构信息

Organ Transplantation Unit, Tel-Aviv Medical Center Tel-Aviv, Israel and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

出版信息

Am J Transplant. 2021 Aug;21(8):2909. doi: 10.1111/ajt.16710. Epub 2021 Jun 18.

DOI:10.1111/ajt.16710
PMID:34080285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8222934/
Abstract
摘要