Boston Univ., United States.
Fraunhofer USA Ctr. for Manufacturing Innovation CMI, United States.
J Biomed Opt. 2021 Jun;26(6). doi: 10.1117/1.JBO.26.6.062708.
Diffuse optical imaging (DOI) provides in vivo quantification of tissue chromophores such as oxy- and deoxyhemoglobin (HbO2 and HHb, respectively). These parameters have been shown to be useful for predicting neoadjuvant treatment response in breast cancer patients. However, most DOI devices designed for the breast are nonportable, making frequent longitudinal monitoring during treatment a challenge. Furthermore, hemodynamics related to the respiratory cycle are currently unexplored in the breast and may have prognostic value.
To design, fabricate, and validate a high optode-density wearable continuous wave diffuse optical probe for the monitoring of breathing hemodynamics in breast tissue.
The probe has a rigid-flex design with 16 dual-wavelength sources and 16 detectors. Performance was characterized on tissue-simulating phantoms, and validation was performed through flow phantom and cuff occlusion measurements. The breasts of N = 4 healthy volunteers were measured while performing a breathing protocol.
The probe has 512 unique source-detector (S-D) pairs that span S-D separations of 10 to 54 mm. It exhibited good performance characteristics: μa drift of 0.34%/h, μa precision of 0.063%, and mean SNR ≥ 24 dB up to 41 mm S-D separation. Absorption contrast was detected in flow phantoms at depths exceeding 28 mm. A cuff occlusion measurement confirmed the ability of the probe to track expected hemodynamics in vivo. Breast measurements on healthy volunteers during paced breathing revealed median signal-to-motion artifact ratios ranging from 8.1 to 8.7 dB. Median ΔHbO2 and ΔHHb amplitudes ranged from 0.39 to 0.67 μM and 0.08 to 0.12 μM, respectively. Median oxygen saturations at the respiratory rate ranged from 82% to 87%.
A wearable diffuse optical probe has been designed and fabricated for the measurement of breast tissue hemodynamics. This device is capable of quantifying breathing-related hemodynamics in healthy breast tissue.
漫射光学成像（DOI）提供组织色团的体内定量，例如氧合血红蛋白（HbO2）和脱氧血红蛋白（HHb）。这些参数已被证明可用于预测乳腺癌患者的新辅助治疗反应。然而，大多数专为乳房设计的 DOI 设备都不可移动，这使得在治疗过程中进行频繁的纵向监测成为一项挑战。此外，与呼吸周期相关的血液动力学目前在乳房中尚未得到探索，并且可能具有预后价值。
设计、制造和验证一种用于监测乳房组织呼吸血液动力学的高光密度可穿戴连续波漫射光学探头。
该探头采用刚性-柔性设计，具有 16 个双波长光源和 16 个探测器。在组织模拟体模上对其性能进行了表征，并通过流量体模和袖带闭塞测量进行了验证。在进行呼吸协议时，对 4 名健康志愿者的乳房进行了测量。
该探头具有 512 个独特的源-探测器（S-D）对，其 S-D 间距为 10 至 54mm。它表现出良好的性能特征：μa 漂移率为 0.34%/h，μa 精度为 0.063%，平均信噪比≥24dB，S-D 分离距离达 41mm。在深度超过 28mm 的流量体模中检测到吸收对比度。袖带闭塞测量证实了探头在体内跟踪预期血液动力学的能力。在健康志愿者进行有节奏呼吸期间进行的乳房测量显示，信号与运动伪影的中位数比值范围为 8.1 至 8.7dB。ΔHbO2 和 ΔHHb 幅度的中位数范围分别为 0.39 至 0.67μM 和 0.08 至 0.12μM。呼吸频率下的中位数氧饱和度范围为 82%至 87%。
设计并制造了一种用于测量乳房组织血液动力学的可穿戴漫射光学探头。该设备能够定量测量健康乳房组织中的呼吸相关血液动力学。
