Department of Emergency and Intensive Care Medicine, Clinical Hospital Dubrava, Avenue Gojko Šušak 6, 10000, Zagreb, Croatia.
Transfusion Medicine Department, Croatian Institute of Transfusion Medicine, Zagreb, Croatia.
Wien Klin Wochenschr. 2021 Nov;133(21-22):1179-1185. doi: 10.1007/s00508-021-01882-3. Epub 2021 Jun 3.
Pulmonary embolism (PE) is a potentially life-threatening condition that mainly affects the people of advanced age. While certain blood group phenotypes (non‑O blood group) are known risk factors for the development of venous thromboembolism (VTE), there is no research which investigated the association of blood group genotypes with severity of PE. The aim of this study was to investigate the frequency of ABO blood group genotypes among the population of patients with PE and to investigate the correlation of the pulmonary embolism severity index (PESI) score to specific ABO blood group genotypes.
In this cross-sectional study 74 patients with PE diagnosed using CT pulmonary angiography were included and 303 blood donors without VTE or congenital thrombophilia participated as a control group. After isolation of genomic DNA ABO blood group genotype was determined using the polymerase chain reaction sequence-specific amplification (PCR-SSP) method.
We observed a significantly higher frequency of A1B and BB genotypes in patients with PE compared to healthy individuals (A1B 14.9% vs. 4.3%, P < 0.001; BB 5.4% vs. 0.7%, P = 0.004), while the O1O1 genotype was significantly less frequent in patients (24.3% vs. 37.3%, P = 0.036). Analyzing the severity of the clinical presentation according to the PESI score, we did not find a correlation between the severity of the clinical presentation and a certain blood type genotype.
Patients with A1B and BB blood type genotype were at increased risk for developing pulmonary embolism, while patients with O1O1 genotype had a significantly lower risk of developing PE.
肺栓塞（PE）是一种潜在的危及生命的疾病，主要影响老年人群。虽然某些血型表型（非 O 血型）是静脉血栓栓塞症（VTE）发展的已知危险因素，但没有研究调查血型基因型与 PE 严重程度的相关性。本研究旨在调查 PE 患者人群中 ABO 血型基因型的频率，并调查肺栓塞严重指数（PESI）评分与特定 ABO 血型基因型的相关性。
在这项横断面研究中，共纳入了 74 例经 CT 肺动脉造影诊断为 PE 的患者，303 名无 VTE 或先天性血栓形成倾向的献血者作为对照组。采用聚合酶链反应序列特异性扩增（PCR-SSP）法分离基因组 DNA 后，确定 ABO 血型基因型。
与健康个体相比，PE 患者中 A1B 和 BB 基因型的频率明显升高（A1B：14.9%比 4.3%，P<0.001；BB：5.4%比 0.7%，P=0.004），而 O1O1 基因型在患者中的频率明显降低（24.3%比 37.3%，P=0.036）。根据 PESI 评分分析临床表现的严重程度，我们未发现临床表现的严重程度与某种血型基因型之间存在相关性。
A1B 和 BB 血型基因型的患者发生肺栓塞的风险增加，而 O1O1 基因型的患者发生 PE 的风险显著降低。
