针对血型抗原的单克隆抗体。
Monoclonal antibodies to blood group antigens.
作者信息
Oei B, Chan S H
机构信息
WHO Immunology Centre, Faculty of Medicine, National University of Singapore.
出版信息
Ann Acad Med Singap. 1988 Apr;17(2):214-7.
PMID:3408223
Abstract
To obtain haemagglutinating monoclonal antibodies as potential blood typing reagents 10 fusions were performed between mouse myeloma cells and spleen cells from mice immunised with either blood group substances or human red blood cells. Nineteen hybridomas with anti-A specificity and 10 with anti-B specificity were generated, Three were selected for further investigations. Some of these hybridoma clones produce and secrete both IgM and IgG.
摘要
为了获得具有血凝活性的单克隆抗体作为潜在的血型鉴定试剂，将小鼠骨髓瘤细胞与用血型物质或人红细胞免疫的小鼠脾细胞进行了10次融合。产生了19个具有抗A特异性的杂交瘤和10个具有抗B特异性的杂交瘤，从中选择了3个进行进一步研究。这些杂交瘤克隆中的一些同时产生并分泌IgM和IgG。
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