Ricciardiello Filippo, Pisani Davide, Viola Pasquale, Pellini Raul, Russo Giuseppe, Longo Giuseppe, Chiarella Giuseppe, Oliva Flavia, Romano Domenico, Petruzzi Gerardo, Mazzone Salvatore
Ear Nose and Throat Unit, Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, vi Antonio Caradelli, Napoli, Italy.
Department of Experimental and Clinical Medicine, Unit of Audiology, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy.
Ear Nose Throat J. 2023 Sep;102(9):NP457-NP465. doi: 10.1177/01455613211001599. Epub 2021 Jun 3.
The aim of this study was to assess the long-term effectiveness of quantic molecular resonance (QMR) in the treatment of inferior turbinate hypertrophy (ITH) in allergic and nonallergic rhinitis refractory to medical therapy.
This study enrolled 281 patients, 160 males (56.9%) and 121 females (43.1%), mean age 37.8 ± 4.1 years, range 18 to 71. Fifty-four patients have been lost to follow up and have been therefore excluded from the final analysis. Based on skin prick test results, 69 patients were considered allergic (group A) and 158 nonallergic (group B). All subjects underwent before surgery (T0) and 3 (T1), 12 (T2), 24 (T3), and 36 months (T4) after QMR treatment to: 4-phase rhinomanometric examination, nasal endoscopy evaluation, and visual analogue scale to quantify the subjective feelings about nasal obstruction.
Subjective and objective parameters showed statistically significant improvement in both groups. Group B parameters not changed during follow-up, while group A showed significant worsening between T1 and subsequent assessments. T4 outcome indicates a better result in nonallergic patients.
In accordance with the literature, our preliminary data validate QMR treatment as a successful therapeutic option for nasal obstruction due to ITH. Nonallergic patients had a very good T4 outcome. Allergic patients showed a worsening trend after 1 year probably due to other causes.
本研究旨在评估量子分子共振（QMR）治疗药物治疗无效的变应性和非变应性鼻炎下鼻甲肥大（ITH）的长期疗效。
本研究纳入281例患者，其中男性160例（56.9%），女性121例（43.1%），平均年龄37.8±4.1岁，年龄范围18至71岁。54例患者失访，因此被排除在最终分析之外。根据皮肤点刺试验结果，69例患者被认为是变应性的（A组），158例是非变应性的（B组）。所有受试者在QMR治疗前（T0）以及治疗后3个月（T1）、12个月（T2）、24个月（T3）和36个月（T4）接受以下检查：四相鼻测压检查、鼻内镜评估以及视觉模拟量表以量化对鼻塞的主观感受。
主观和客观参数在两组中均显示出统计学上的显著改善。B组参数在随访期间未发生变化，而A组在T1及后续评估之间显示出显著恶化。T4期结果表明非变应性患者的治疗效果更好。
与文献一致，我们的初步数据证实QMR治疗是治疗ITH所致鼻塞的一种成功的治疗选择。非变应性患者在T4期有非常好的治疗效果。变应性患者在1年后显示出恶化趋势，可能是由于其他原因。
