Chastagner P, Olive D, Philip T, Zucker J M, Czorny A, Lapras C, Brunat-Mentigny M
Hôpital d'Enfants, Service de Pédiatrie II, Nancy.
Arch Fr Pediatr. 1988 Apr;45(4):249-54.
In the present study, the "8 drugs in 1 day" regimen was tested in 54 children: 27 relapses (brain and/or spinal and/or meningeal sites), 10 refractory progressive diseases, 13 macroscopic residual tumors after partial excision and/or radiotherapy; in 4 cases, this regimen was prescribed as first line treatment. The response rate (complete and partial remission) was 46%. Results were very encouraging in medalloblastomas with a response rate of 76.5% whereas in brain stem gliomas it was only 23% and 33% in other astrocytomas. Immediate toxicity, mainly hematological, was very moderate. These results justify to propose this regimen as adjuvant chemotherapy, mostly in medulloblastomas and to plan other similar trials, using the most active drugs which seem presently to be alkylating and platinum-derived agents.
在本研究中，对54名儿童进行了“一日八药”方案的测试：27例复发（脑部和/或脊髓和/或脑膜部位）、10例难治性进展性疾病、13例部分切除和/或放疗后肉眼可见的残留肿瘤；4例中，该方案被作为一线治疗方案。缓解率（完全缓解和部分缓解）为46%。在成神经管细胞瘤中结果非常令人鼓舞，缓解率为76.5%，而在脑干胶质瘤中仅为23%，在其他星形细胞瘤中为33%。即刻毒性，主要是血液学毒性，非常轻微。这些结果证明将该方案作为辅助化疗是合理的，主要用于成神经管细胞瘤，并计划开展其他类似试验，使用目前看来最有效的药物，即烷化剂和铂类药物。
