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[儿童脑肿瘤的化疗]

[Chemotherapy of brain tumors in children].

作者信息

Chastagner P, Olive-Sommelet D

机构信息

Service de Médecine Infantile II, Hôpital d'Enfants, Vandoeuvre-lès-Nancy.

出版信息

Arch Fr Pediatr. 1990 Feb;47(2):147-54.

PMID:2183741
Abstract

The present recovery rate of brain tumors (20% of solid tumors in children) is 50%. Besides the progress made in neurosurgery and radiotherapy, those of chemotherapy have indisputably had an impact on the improvement of the rate of recovery. Protocols in use differ according to the histologic type of the tumor (astrocytoma, glioma, medulloblastoma). Indications for therapeutic trials for phase II and III tumors will require a longer period of follow-up as well as strict analysis of the result.

摘要

目前脑肿瘤的治愈率(儿童实体瘤的20%)为50%。除了神经外科手术和放射治疗取得的进展外,化疗进展无疑对治愈率的提高产生了影响。所使用的方案因肿瘤的组织学类型(星形细胞瘤、神经胶质瘤、髓母细胞瘤)而异。II期和III期肿瘤治疗试验的适应症需要更长的随访期以及对结果进行严格分析。

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