基于知识的容积调强弧形治疗计划的复杂性和交付精度，用于口咽癌的单次优化。

Plan Complexity and Delivery Accuracy of Knowledge-based Volumetric Modulated Arc Therapy Plans with Single Optimization for Oropharyngeal Cancer.

机构信息

Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osaka, Japan.

Department of Radiology, Kansai Electric Power Hospital, Osaka, Japan.

出版信息

Anticancer Res. 2021 Jun;41(6):2925-2931. doi: 10.21873/anticanres.15074.

DOI:10.21873/anticanres.15074

PMID:34083283

Abstract

BACKGROUND/AIM: We investigated the plan complexity of volumetric modulated arc therapy (VMAT) with knowledge-based plan (KBP) for oropharyngeal cancer (OPC) with a single optimization and whether it could be used clinically.

MATERIALS AND METHODS

KBP model was configured using 55 consecutive OPC and nasopharyngeal cancer plans. Plan complexity as a characteristic of multileaf collimator (MLC) motion and γ pass rate (2%/2 mm criterion) were compared between clinical manual plan (CMP) and KBP for other 10 plans.

RESULTS

Plan complexity metrics that had significant differences (p<0.05) (CMP vs. KBP), were mean lateral displacement of MLC from central axis (15.82 mm vs. 18.90 mm), proportions of MLC aperture sizes of ≤5 mm (0.14 vs. 0.11), ≤10 mm (0.24 vs. 0.19), and ≤20 mm (0.41 vs. 0.34), and monitor units (578.68 vs. 505.04). The γ pass rate was 91.3% vs. 93.3%.

CONCLUSION

Single optimized KBP for OPC had simple plan complexity features and comparable delivery accuracy to CMP, and could be clinically applied.

摘要

背景/目的：我们研究了基于知识的计划（KBP）的单优化容积调强弧形治疗（VMAT）在口咽癌（OPC）中的计划复杂性，以及其是否可在临床上应用。

材料与方法

使用 55 例连续的 OPC 和鼻咽癌计划配置 KBP 模型。对其他 10 例计划的临床手动计划（CMP）和 KBP 之间的多叶准直器（MLC）运动特性和γ通过率（2%/2mm 标准）的计划复杂性指标进行了比较。

结果

MLC 从中轴线侧向位移（15.82mm 比 18.90mm）、≤5mm、≤10mm 和≤20mm 的 MLC 孔径尺寸比例（0.14 比 0.11、0.24 比 0.19 和 0.41 比 0.34）和监测器单位（578.68 比 505.04）有显著差异（p<0.05）（CMP 比 KBP）。γ通过率为 91.3%比 93.3%。