Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osaka, Japan.
Department of Radiology, Kansai Electric Power Hospital, Osaka, Japan.
Anticancer Res. 2021 Jun;41(6):2925-2931. doi: 10.21873/anticanres.15074.
BACKGROUND/AIM: We investigated the plan complexity of volumetric modulated arc therapy (VMAT) with knowledge-based plan (KBP) for oropharyngeal cancer (OPC) with a single optimization and whether it could be used clinically.
KBP model was configured using 55 consecutive OPC and nasopharyngeal cancer plans. Plan complexity as a characteristic of multileaf collimator (MLC) motion and γ pass rate (2%/2 mm criterion) were compared between clinical manual plan (CMP) and KBP for other 10 plans.
Plan complexity metrics that had significant differences (p<0.05) (CMP vs. KBP), were mean lateral displacement of MLC from central axis (15.82 mm vs. 18.90 mm), proportions of MLC aperture sizes of ≤5 mm (0.14 vs. 0.11), ≤10 mm (0.24 vs. 0.19), and ≤20 mm (0.41 vs. 0.34), and monitor units (578.68 vs. 505.04). The γ pass rate was 91.3% vs. 93.3%.
Single optimized KBP for OPC had simple plan complexity features and comparable delivery accuracy to CMP, and could be clinically applied.
背景/目的：我们研究了基于知识的计划（KBP）的单优化容积调强弧形治疗（VMAT）在口咽癌（OPC）中的计划复杂性，以及其是否可在临床上应用。
使用 55 例连续的 OPC 和鼻咽癌计划配置 KBP 模型。对其他 10 例计划的临床手动计划（CMP）和 KBP 之间的多叶准直器（MLC）运动特性和γ通过率（2%/2mm 标准）的计划复杂性指标进行了比较。
MLC 从中轴线侧向位移（15.82mm 比 18.90mm）、≤5mm、≤10mm 和≤20mm 的 MLC 孔径尺寸比例（0.14 比 0.11、0.24 比 0.19 和 0.41 比 0.34）和监测器单位（578.68 比 505.04）有显著差异（p<0.05）（CMP 比 KBP）。γ通过率为 91.3%比 93.3%。
用于 OPC 的单优化 KBP 具有简单的计划复杂性特征，与 CMP 的传输精度相当，可在临床上应用。
