Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi Province, China.
Department of Emergency, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi Province, China.
Sci Rep. 2021 Jun 3;11(1):11752. doi: 10.1038/s41598-021-91151-0.
To explore the difference of curative effect between different treatment modalities, in order to provide reference for the treatment of aortic intramural hematoma (IMH). 168 patients with aortic intramural hematoma diagnosed and treated from January 2010 to July 2020 were selected in the Second Affiliated Hospital of Nanchang University. Among them, 48 patients were diagnosed with Stanford A aortic intramural hematoma and 120 were diagnosed with Stanford B aortic intramural hematoma. According to the therapeutic methods, patients were divided into conservative treatment group and endovascular treatment group (TEVAR). For endovascular treatment group, according to the different timing of surgery, can be divided into acute phase group (onset within 72 h) and non-acute phase group (time of onset > 72 h).The clinical data and follow-up data were collected and analyzed by variance analysis and χ test. There were 168 patients diagnosed with aortic intramural hematoma 39 of them were (81.25%) Stanford A aortic intramural hematoma patients with pleural or pericardial effusion. For patient with Stanford A aortic intramural hematoma, endovascular treatment was performed in 15 patients (31.2%), and 33 cases (68.8%) for conservative treatment. The average follow-up (24.9 ± 13.9) was months. There were 120 patients with Stanford type B aortic intramural hematoma (71.4%), 60 patients received endovascular treatment (50%), and 60 patients (50%) received conservative treatment, with an average follow-up of (27.8 ± 14.6) months. For Stanford A type aortic intramural hematoma patients when the maximum aortic diameter ≥ 50 mm or hematoma thickness ≥ 11 mm, with high morbidity and mortality, positive endovascular treatment can reduce complications and death. For patients with Stanford type B aortic intramural hematoma, when the maximum aortic diameter ≥ 40 mm or hematoma thickness ≥ 10 mm, with high morbidity and mortality, positive endovascular treatment can reduce complications and death. Both Stanford type A and B aortic intramural hematoma patients could benefit from the endovascular treatment when the initial maximum aortic diameter is ≥ 50 mm or the hematoma thickness is ≥ 11 mm.
为了探讨不同治疗方式的疗效差异,为主动脉壁内血肿(IMH)的治疗提供参考。选择 2010 年 1 月至 2020 年 7 月南昌大学第二附属医院收治的 168 例主动脉壁内血肿患者,其中 Stanford A 型主动脉壁内血肿患者 48 例,Stanford B 型主动脉壁内血肿患者 120 例。根据治疗方法,患者分为保守治疗组和血管内治疗组(TEVAR)。对于血管内治疗组,根据手术时机的不同,可分为急性期组(发病 72h 内)和非急性期组(发病时间>72h)。通过方差分析和 χ 检验收集和分析临床资料和随访资料。共诊断主动脉壁内血肿患者 168 例,其中 Stanford A 型主动脉壁内血肿患者 39 例(81.25%)合并胸腔或心包积液。对于 Stanford A 型主动脉壁内血肿患者,行血管内治疗 15 例(31.2%),保守治疗 33 例(68.8%)。平均随访(24.9±13.9)个月。Stanford B 型主动脉壁内血肿患者 120 例(71.4%),行血管内治疗 60 例(50%),保守治疗 60 例(50%),平均随访(27.8±14.6)个月。对于 Stanford A 型主动脉壁内血肿患者,当最大主动脉直径≥50mm 或血肿厚度≥11mm 时,发病率和死亡率较高,积极的血管内治疗可降低并发症和死亡率。对于 Stanford B 型主动脉壁内血肿患者,当最大主动脉直径≥40mm 或血肿厚度≥10mm 时,发病率和死亡率较高,积极的血管内治疗可降低并发症和死亡率。无论是 Stanford A 型还是 B 型主动脉壁内血肿患者,当初始最大主动脉直径≥50mm 或血肿厚度≥11mm 时,均可从血管内治疗中获益。