小鼠双微体2基因309T>G多态性与视网膜母细胞瘤风险：一项荟萃分析。
The mouse double minute 2 309T>G polymorphism and retinoblastoma risk: A meta-analysis.
作者信息
Sooraj K, Kumar Sunil, Kumar Amit, Bajaj Mandeep S, Kaur Jasbir
机构信息
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Saudi J Ophthalmol. 2021 Feb 27;34(3):191-194. doi: 10.4103/1319-4534.310402. eCollection 2020 Jul-Sep.
PURPOSE
Mouse double minute 2 (MDM2) homolog is a protein that in humans is encoded by the MDM2 gene. It is expressed in retinoblastoma (Rb) cells and acts as a key negative regulator of the p53 tumor suppressor gene. Several studies have investigated the association of Rb with MDM2 309T>G polymorphism, but the results were conflicting. To derive a more precise estimation of the association, we performed a meta-analysis of the relationship between MDM2 309T>G polymorphism with Rb in all published studies.
METHODS
Published literature from PubMed and other databases were retrieved. All the reported studies evaluating the association between MDM2 309T>G polymorphism and Rb risk were included. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using the fixed-effect model. A total of four case-control studies, including 520 cases and 745 controls were included.
RESULTS
This meta-analysis found that MDM2 309T>G polymorphism was significantly associated with Rb risk in the dominant model, TG+GG versus TT (OR = 1.43, 95% CI = 1.11-1.84, = 0.006).
CONCLUSION
The present meta-analysis suggested that MDM2 309T>G polymorphism has a significant association with increased Rb risk.
目的
小鼠双微体2（MDM2）同源物是一种在人类中由MDM2基因编码的蛋白质。它在视网膜母细胞瘤（Rb）细胞中表达，并且作为p53肿瘤抑制基因的关键负调节因子发挥作用。多项研究调查了Rb与MDM2 309T>G多态性之间的关联，但结果相互矛盾。为了更精确地估计这种关联，我们对所有已发表研究中MDM2 309T>G多态性与Rb之间的关系进行了荟萃分析。
方法
从PubMed和其他数据库检索已发表的文献。纳入所有评估MDM2 309T>G多态性与Rb风险之间关联的报道研究。使用固定效应模型计算合并优势比（OR）和95%置信区间（CI）。总共纳入了四项病例对照研究，包括520例病例和745例对照。
结果
这项荟萃分析发现，在显性模型（TG+GG与TT相比）中，MDM2 309T>G多态性与Rb风险显著相关（OR = 1.43，95%CI = 1.11 - 1.84，P = 0.006）。
结论
本荟萃分析表明，MDM2 309T>G多态性与Rb风险增加显著相关。
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