钯催化的缺电子多氟芳烃与偕二氟环丙烷的 C-H 烯丙基化反应。
Palladium-Catalyzed C-H Allylation of Electron-Deficient Polyfluoroarenes with gem-Difluorinated Cyclopropanes.
机构信息
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453000, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.
出版信息
Org Lett. 2021 Jun 18;23(12):4920-4924. doi: 10.1021/acs.orglett.1c01699. Epub 2021 Jun 4.
A palladium-catalyzed C-H allylation of electron-deficient polyfluoroarenes with gem-difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2-fluoroallylic polyfluoroarenes in moderate to excellent yields with high Z-selectivity. In addition, this new approach has good functional group compatibility and broad substrate scope.
报道了钯催化的缺电子多氟芳烃与偕二氟环丙烷的 C-H 烯丙基化反应。该方法提供了一种有用且简便的方法，以中等至优异的收率和高 Z 选择性得到 2-氟烯丙基多氟芳烃。此外，这种新方法具有良好的官能团相容性和广泛的底物范围。
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