Nephrology Service, General University Hospital of Alicante-ISABIAL, Alicante, Spain.
Department of Clinical Medicine, University Miguel Hernandez, Alicante, Spain.
Nucleosides Nucleotides Nucleic Acids. 2021;40(7):720-731. doi: 10.1080/15257770.2021.1934482. Epub 2021 Jun 4.
Hemodialysis adequately controls serum uric acid (UA) levels, making UA-lowering drugs unnecessary; scant data are available for peritoneal dialysis (PD). We analyzed blood, 24 h urine and dialysis fluid from twenty patients under PD, to assess UA levels and clearances, and factors associated with better performance and maintenance of target levels (<6mg/dL). Median serum UA was 5.4 mg/dL (p25-75 4.4-5.8), mainly achieved through peritoneal clearance (3.0 mL/min/1.73m, 71.2% of total UA clearance); 75% of participants was on UA targets. Continuous cycling peritoneal dialysis showed highest UA clearance and target achievements. These findings may be of interest for end-stage renal patients with gout.
血液透析能充分控制血清尿酸（UA）水平，使降尿酸药物变得不必要；腹膜透析（PD）的数据则很少。我们分析了 20 名 PD 患者的血液、24 小时尿液和透析液，以评估 UA 水平和清除率，以及与更好的表现和维持目标水平（<6mg/dL）相关的因素。中位血清 UA 为 5.4mg/dL（p25-75 4.4-5.8），主要通过腹膜清除（3.0mL/min/1.73m，占总 UA 清除率的 71.2%）实现；75%的参与者达到了 UA 目标。持续循环腹膜透析显示出最高的 UA 清除率和目标达成率。这些发现可能对患有痛风的终末期肾病患者有意义。
