Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
PLoS One. 2021 Jun 4;16(6):e0252642. doi: 10.1371/journal.pone.0252642. eCollection 2021.
Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice.
血红素加氧酶-1（HO-1）是一种进化上保守的应激反应酶，在妊娠维持、胎儿和新生儿结局以及多种病理情况下都很重要。在这里，我们研究了在妊娠晚期（胚胎第 15.5 天）全身炎症暴露对野生型（Wt）和 HO-1 杂合子（Het，HO-1+/-）母亲、胎儿和后代的影响。我们表明，在妊娠晚期炎症期间，胎儿肝脏和脾脏 HO 动态平衡的改变会导致小鼠在幼年期（出生后第 25 天）脾脏中固有免疫细胞群和细胞内髓样 HO-1表达的持续失调。
